625836-85-3Relevant academic research and scientific papers
SULFUR-CONTAINING NAPHTHOYLIMIDE DERIVATIVES
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Page/Page column 8, (2008/06/13)
The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.
Synthesis of thiazo- or thiadiazo- naphthalene carboxamides via mercuric intermediates and their antitumor and DNA photocleavage activities
Li, Zhigang,Yang, Qing,Qian, Xuhong
, p. 6634 - 6641 (2007/10/03)
Two kinds of thiazo- or thiadiazo- naphthalene carboxamides with aminoalkyl side chains at 5- or 6-position modified from naphthalimides were designed, synthesized and quantitatively evaluated as antitumor and DNA photocleaving agents. The compound with a
Thio-heterocylic naphthalimides with aminoalkyl side chains: Novel alternative tools for photodegradation of genomic DNA without impairment on bioactivities of proteins
Yang, Qing,Qian, Xuhong,Xu, Jianqiang,Sun, Yuanshe,Li, Yonggang
, p. 1615 - 1622 (2007/10/03)
Thio-heterocylic naphthalimides (R1-R5) were designed, synthesized and evaluated as nonmetallic and long-wavelength photocleavers. Some of them showed highly efficient abilities in the degradation of plasmid and genomic DNA under the mild conditions witho
