62584-11-6Relevant academic research and scientific papers
Divergent Synthesis of Methylisatoid and Tryptanthrin Derivatives by Ph3P-I2-Mediated Reaction of Isatins with and without Alcohols
Pattarawarapan, Mookda,Wiriya, Nittaya,Hongsibsong, Surat,Phakhodee, Wong
supporting information, p. 15743 - 15751 (2020/12/23)
A novel phosphonium-mediated reaction of isatins is described. In the presence of alcohol, the reaction proceeds to furnish C-12 modified tryptanthrin derivatives. Without alcohol, self-dimerization of isatins gives rise to tryptanthrin and its analogs. T
Isatin chloride: A phantom. Reactions of 2-(2,2-dichloro-2,3-dihydro-3-oxoindol-1-yl)-3H-indol-3-one
Cornforth, John,Hitchcock, Peter B.,Rozos, Panteleimon
, p. 2787 - 2792 (2007/10/03)
It is shown that 2-chloro-3H-indol-3-one 1 and analogues have never actually been isolated and that their reactions, reported over 115 years in 40 papers and 4 patents, are those of more or less impure 2-(2,2-dichloro-2,3-dihydro-3-oxoindol-1-yl)-3H-indol-3-one 14. Several reactions of the parent compound and its 5,5′-dimethyl and 5,5′-dibromo derivatives are reported, especially a reaction with dry methanol leading to the known indoloquinazoline 25 ('methylisatoid') and to the known alkaloid tryptanthrin 21 via a photolabile orthoester.
