62596-23-0

Upstream product

• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 672-65-1 (1-chloroethyl)benzene 
• 585-71-7 (1-bromoethyl)benzne 
• 98-85-1 1-Phenylethanol 
• 1424-22-2 1-cyclohexenyl acetate 
• 14856-75-8 1-phenyl-1-trimethylsilyloxyethane 
• 93-92-5 1-phenylethyl acetate 
• 5682-83-7 (E)-2-benzylidenecyclohexanone 
• 75-24-1 trimethylaluminum 
• 98-86-2 acetophenone 

Relevant academic research and scientific papers

Stereoselective Hydrogenation of Tetrasubstituted Enones

Contiguous tertiary asymmetric centers were constructed stereoselectively by cis-hydrogenation of tetrasubstituted (E)-enones using Rh/alumina catalyst.

Rhenium-catalyzed α-alkylation of enol acetates with alcohols or ethers

When benzylic and allylic alcohols were treated with enol acetate in the presence of a catalytic amount of a rhenium complex, ReBr(CO)5, the carbon-carbon bond formation of the alcohols and enol acetate smoothly proceeded to give the corresponding ketones and aldehyde in moderate to good yields. For the reaction of allylic alcohols, γ,δ-unsaturated carbonyl compounds were obtained in good yields. When ethers were used instead of alcohols as the alkylated agent, two alkyl moieties on the ethers were utilized on the reaction.

Copper-Catalyzed Asymmetric Conjugate Addition to α-Alkylidene Cycloalkanones

The asymmetric copper-catalyzed conjugate addition to α-alkylidene cycloalkanones, substituted at their terminal position with aromatic and aliphatic groups, is reported. While high enantioselectivity is reached using chiral phosphoramidite ligands, with R3Al reagents, moderate diastereoselectivity was observed upon hydrolysis of the aluminium enolates. A Grignard reagent also react with high diastereoselectivity.

Rhenium complex-catalyzed coupling reaction of enol acetates with alcohols

The reaction of enol acetates with alcohols in the presence of a catalytic amount of a rhenium complex, such as ReBr(CO)5, produced the corresponding ketones and aldehydes in moderate to good yields. It was suggested that the preparation of an ether, an intermolecular dehydrated product, was the first step of the reaction.

InCl3/Me3SiBr-catalyzed direct coupling between silyl ethers and enol acetates

A combined Lewis acid catalyst of InCl3 and Me3SiBr promoted the direct use of enol acetates in the coupling with low-reactive silyl ethers, in which functional groups including ketones and aldehydes survived. Sterically hindered silyl ethers such as ROSiEt3, ROSiPh3, ROSit-BuMe2, and ROSii-Pr3 were also applicable.

InI3/me3sii-catalyzed direct alkylation of enol acetates using alkyl acetates or alkyl ethers

A combined Lewis acid of InI3 and Me3SiI was used to catalyze the direct coupling reactions of enol acetates with alkyl acetates or alkyl ethers without generating metal waste. The easily-handled alkylating reagents enlarged the application area of this coupling reaction. 2011 The Chemical Society of Japan.

α-Alkylation of carbonyl compounds by direct addition of alcohols to Enol acetates

A practical α-alkylation of ketones and aldehydes has been achieved by the direct addition of alcohols to enol acetates. The moderate Lewis acidity of InI3, CaBr3, and FeBr3 is a key factor in the catalytic cycle, and many different alcohols and enol acetates have been successfully used in this procedure.

MGLUR5 ANTAGONISTIC CARBAMOYL-OXIME DERIVATIVES

The present invention relates to new mGluR5 receptor subtype preferring ligands of formula (I): (I) wherein R1 and R2 represent independently a substituent selected from hydrogen, halogen, alkyl, alkoxy, haloalkyl and cyano; X is a C

Regioselective Lewis Acid-mediated α-sec-Alkylation of Carbonyl Compounds

Carbonyl compounds such as ketones, aldehydes, acyloins, or carboxylic esters can be alkylated at the α-position via the corresponding O-silylated forms using activated alkyl halides or acetates in the presence of Lewis acids.In the case of unsymmetricall