62620-71-7

Usage

Uses

Used in Pharmaceutical Industry:
6-(Trifluoromethyl)-2,3,4-trihydronaphthalen-1-one is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. It serves as a key building block in the synthesis of Bergenin, a natural product with hepatoprotective and antioxidant properties, which can be used for the development of drugs targeting liver diseases.
Additionally, 6-(Trifluoromethyl)-2,3,4-trihydronaphthalen-1-one is used as a reagent in the synthesis of (±)-Preclamol, a partial dopamine D2 agonist. 6-(Trifluoromethyl)-2,3,4-trihydronaphthalen-1-one is utilized in the treatment of Parkinson's disease, a neurodegenerative disorder characterized by the loss of dopaminergic neurons and motor impairments. The use of 6-(Trifluoromethyl)-2,3,4-trihydronaphthalen-1-one in the synthesis of (±)-Preclamol contributes to the development of therapeutic agents for managing Parkinson's disease symptoms and improving patient quality of life.

Upstream product

• 145485-43-4 4-(3-(trifluoromethyl)phenyl)butanoic acid 
• 88699-88-1 5-oxo-5-(4-(trifluoromethyl)phenyl)pentanoic acid 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 29480-10-2 1-(4-(trifluoromethyl)phenyl)cyclobutan-1-ol 

Relevant academic research and scientific papers

Visible-light-induced oxidation/[3 + 2] cycloaddition/oxidative aromatization to construct benzo[ a]carbazoles from 1,2,3,4-tetrahydronaphthalene and arylhydrazine hydrochlorides

An efficient synthesis of benzo[a]carbazoles via visible-light-induced tandem oxidation/[3 + 2] cycloaddition/oxidative aromatization reactions was reported. The benzylic C(sp3)-H of tetrahydronaphthalene was activated through visible-light photoredox catalyst with oxygen as the clean oxidant under mild reaction conditions. This protocol proceeds efficiently with broad substrate scope, and the mechanism study was performed.

Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and electron-rich and electron-deficient arenes and heteroarenes are viable reaction substrates. This reaction enables access to a diverse set of fused, partially saturated cores which are of high interest in synthetic and medicinal chemistry.

A rapid method for open-loop/oxidation based on substituted cyclobutanol cyclization reaction preparation Tetralone derivatives (by machine translation)

The invention discloses a method for quickly based on substituted cyclobutanol oxidation open-loop/cyclization reaction preparation Tetralone derivatives of the method, the method is that the aryl substituted cyclobutanol cerium amine in the nitric acid oxidation of a pot of reaction under the action of the generating Tetralone derivatives; this method has the advantages of fast response (30 seconds in the completion of the reaction), the operation is simple (the open reaction), mild reaction conditions, one-step reaction, does not need to use noble metal catalytic, the yield is high, can be expands the quantity reaction and the like, overcome in the prior art long reaction time, requires the use of a noble metal catalyst, more reaction steps, more byproducts and the like. (by machine translation)

Tandem Oxidative Ring-Opening/Cyclization Reaction in Seconds in Open Atmosphere for the Synthesis of 1-Tetralones in Water-Acetonitrile

A mild and practical tandem oxidative ring-opening/cyclization reaction mediated by Ce4+ for the synthesis of 1-tetralones is presented. This rapid transformation was completed within 30 s and conducted in an open reactor at 0 °C in a water-acetonitrile mixture. Various cyclobutanol derivatives are transformed into desired products in good to high yields, and this reaction can be easily scaled up to the gram scale.

Tandem Oxidative Ring-Opening/Cyclization Reaction in Seconds in Open Atmosphere for the Synthesis of 1-Tetralones in Water-Acetonitrile

A mild and practical tandem oxidative ring-opening/cyclization reaction mediated by Ce4+ for the synthesis of 1-tetralones is presented. This rapid transformation was completed within 30 s and conducted in an open reactor at 0 °C in a water-acetonitrile mixture. Various cyclobutanol derivatives are transformed into desired products in good to high yields, and this reaction can be easily scaled up to the gram scale.

A facile and regioselective synthesis of 1-tetralones via silver-catalyzed ring expansion

A regioselective synthesis of 1-tetralones via silver-catalyzed ring expansion is described. A variety of 1-tetralones are furnished under mild reaction conditions from tertiary cyclobutanols regardless of the electronic properties and steric hindrance of substituents, providing a new and practical method to access diverse 1-tetralone building blocks. Preliminary experimental and DFT studies revealed that a radical-mediated sequence of C-C bond cleavage/C-C bond formation is involved.

Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same

The subject of the invention is tricyclic derivatives of pyrazolecarboxylic acid of formula: in which R1 represents a C3-C15 carboxyl radical or an NR2R3 group. The invention also relates to the method for preparing the compounds of formula (I), pharmaceutical compositions containing them. The compounds of formula (I) are active on cannabinoid CB1 receptors.