88699-88-1

Basic information

• Product Name: 5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERIC ACID
• Synonyms: 5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERIC ACID
• CAS NO: 88699-88-1
• Molecular Formula: C₁₂H₁₁F₃O₃
• Molecular Weight: 260.21
• Mol File: 88699-88-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 397.2°C at 760 mmHg
• Flash Point: 194°C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 5.06E-07mmHg at 25°C
• Refractive Index: 1.482
• CAS DataBase Reference: 5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERIC ACID(88699-88-1)
• EPA Substance Registry System: 5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERIC ACID(88699-88-1)

Safety Data

• Hazardous Substances Data: 88699-88-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H11F3O3/c13-12(14,15)9-6-4-8(5-7-9)10(16)2-1-3-11(17)18/h4-7H,1-3H2,(H,17,18)

Upstream product

• 108-55-4 glutaric anhydride, 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 

Downstream Products

• 62620-71-7 6-(trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1261280-20-9 5-(4-(trifluoromethyl)phenyl)hex-5-enoic acid 

Relevant articles and documents

Aryl Boronic Acid Catalysed Dehydrative Substitution of Benzylic Alcohols for C?O Bond Formation

A combination of pentafluorophenylboronic acid and oxalic acid catalyses the dehydrative substitution of benzylic alcohols with a second alcohol to form new C?O bonds. This method has been applied to the intermolecular substitution of benzylic alcohols to form symmetrical ethers, intramolecular cyclisations of diols to form aryl-substituted tetrahydrofuran and tetrahydropyran derivatives, and intermolecular crossed-etherification reactions between two different alcohols. Mechanistic control experiments have identified a potential catalytic intermediate formed between the aryl boronic acid and oxalic acid.

Ru-catalyzed asymmetric hydrogenation of δ-keto Weinreb amides: Enantioselective synthesis of (+)-Centrolobine

An efficient asymmetric hydrogenation of δ-keto Weinreb amides catalyzed by a Ru-Xyl-SunPhos-Daipen bifunctional catalyst has been achieved. This method afforded a series of enantio-enriched δ-hydroxy Weinreb amides in good yields (up to 93%) and enantioselectivities (up to 99%). This protocol was successfully applied to the synthesis of the key intermediate of (+)-Centrolobine.

CCR2 RECEPTOR ANTAGONISTS

The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.