626218-49-3Relevant academic research and scientific papers
Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor
Tran, Joe A.,Pontillo, Joseph,Fleck, Beth A.,Marinkovic, Dragan,Arellano, Melissa,Tucci, Fabio C.,Lanier, Marion,Saunders, John,Jiang, Wanlong,Chen, Caroline W.,Foster, Alan C.,Chen, Chen
, p. 3693 - 3696 (2006)
A series of 2-pyridinylpiperazines derived from β-Ala-(2,4-Cl)Phe dipeptide was synthesized for the study of their SARs and possible interactions with the MC4 receptor. Compounds such as 11k (Ki = 6.5 nM) possessed high potency.
