Bioorganic and Medicinal Chemistry Letters p. 3693 - 3696 (2006)
Update date:2022-08-05
Topics:
Tran, Joe A.
Pontillo, Joseph
Fleck, Beth A.
Marinkovic, Dragan
Arellano, Melissa
Tucci, Fabio C.
Lanier, Marion
Saunders, John
Jiang, Wanlong
Chen, Caroline W.
Foster, Alan C.
Chen, Chen
A series of 2-pyridinylpiperazines derived from β-Ala-(2,4-Cl)Phe dipeptide was synthesized for the study of their SARs and possible interactions with the MC4 receptor. Compounds such as 11k (Ki = 6.5 nM) possessed high potency.
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