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Harringtonine, a natural alkaloid compound, is derived from the plant Cephalotaxus harringtonia, commonly referred to as the English yew. It is recognized for its potent inhibitory effect on protein biosynthesis, which has been instrumental in the treatment of chronic myeloid leukemia. harringtonine's mechanism of action involves binding to the ribosome, thereby preventing the elongation factor from delivering aminoacyl-tRNAs to the ribosome and inhibiting the synthesis of new proteins. Harringtonine's complex chemical structure has garnered significant attention in research for its potential therapeutic applications, including the treatment of other cancer types and the enhancement of the efficacy of other anticancer drugs.

62624-24-2

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62624-24-2 Usage

Uses

Used in Oncology:
Harringtonine is utilized as an anticancer agent, specifically for the treatment of chronic myeloid leukemia. It functions by inhibiting protein biosynthesis through its binding to the ribosome, which prevents the elongation factor from delivering aminoacyl-tRNAs, thereby hindering the synthesis of new proteins. This action has demonstrated effectiveness in managing the progression of the disease.
Additionally, Harringtonine has shown potential in the treatment of other types of cancer. Its ability to inhibit protein biosynthesis makes it a candidate for further research and development in oncology, with the aim of expanding its applications to various cancer types.
Used in Enhancing Anticancer Drug Efficacy:
Harringtonine is also studied for its potential to enhance the efficacy of other anticancer drugs. By combining it with existing chemotherapeutic agents, researchers are exploring the possibility of improving treatment outcomes and overcoming drug resistance in cancer therapy. This application could lead to more effective cancer treatment strategies and better patient outcomes.

Check Digit Verification of cas no

The CAS Registry Mumber 62624-24-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,6,2 and 4 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 62624-24:
(7*6)+(6*2)+(5*6)+(4*2)+(3*4)+(2*2)+(1*4)=112
112 % 10 = 2
So 62624-24-2 is a valid CAS Registry Number.
InChI:InChI=1/C28H37NO9/c1-26(2,32)8-9-28(33,15-22(30)35-4)25(31)38-24-21(34-3)14-27-7-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,32-33H,5-11,15-16H2,1-4H3/t23-,24-,27?,28?/m1/s1

62624-24-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name harringtonine

1.2 Other means of identification

Product number -
Other names epi-Harringtonine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:62624-24-2 SDS

62624-24-2Downstream Products

62624-24-2Relevant academic research and scientific papers

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