24316-19-6

Usage

Uses

Used in Pharmaceutical Industry:
Cephalotaxine is used as an antiviral and antitumor agent for its ability to combat various viral and tumor-related conditions. Its potent biological activities contribute to its potential as a therapeutic agent in the treatment of diseases caused by viruses and cancer cells.
Used in Antiviral Applications:
Cephalotaxine is employed as an antiviral agent, targeting and inhibiting the replication of various viruses. Its effectiveness in this application can lead to the development of new antiviral drugs and treatments.
Used in Antitumor Applications:
Cephalotaxine is used as an antitumor agent, particularly in the treatment of cancer. It has shown potential in inhibiting the growth and proliferation of tumor cells, making it a promising candidate for the development of novel cancer therapies.

InChI:InChI=1/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3

Upstream product

• 917-64-6 methyl magnesium iodide 
• 84395-19-7 Methyl 3-carbocephalotaxyl-3-hydroxy-7-oxooctanoate 
• 38750-57-1 (±)-cephalotaxinone 

Downstream Products

• 61568-68-1 (3aR)-1t-benzoyloxy-2-methoxy-(3arC⁴,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepine 
• 61568-71-6 (3aR)-1t-benzyloxycarbonyloxy-2-methoxy-(3arC⁴,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepine 
• 1040272-38-5 (1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-4-oxooxetane-2-carboxylate 
• 1040272-14-7 1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-((E)-4-(benzyloxy)-4-methylpent-2-en-1-yl)-2-hydroxysuccinate 
• 36804-95-2 deoxyharringtonine 
• 52729-50-7 epi-deoxyharringtonine 
• 54086-27-0 (3-methyl-butyl)-butenedioic acid 1-((3aR)-2-methoxy-(3arC⁴,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-yl) ester 4-methyl ester 

Relevant academic research and scientific papers

ANALOGUES AND DERIVATIVES OF CEPHALOTAXINE AND METHODS FOR MAKING AND USING THE COMPOUNDS

Disclosed herein are embodiments of a compound having a Formula I, or a salt, solvate, N-oxide, prodrug, diastereomer or enantiomer thereof. Also disclosed are derivative compounds made from the compound of Formula I. Certain derivative compounds have a Formula V-2, or a salt, solvate, N-oxide, prodrug, diastereomer or enantiomer thereoAlso disclosed are method for making and using the disclosed compounds. Certain disclosed embodiments are useful for treating and/or preventing certain diseases and/or disorders, including proliferation diseases, such as leukemia.

Novel cephalotaxane derivatives and process for their preparation

The present invention concerns a new general process for asymetric hemisynthesis of harringtonines and their analogs, that are alcalo?ds used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.

Studies in Cephalotaxus Alkaloids. Stereospecific Total Synthesis of Homoharringtonine

The alkaloid ester homoharringtonine (2) was synthesized stereospecifically via the Reformatsky reaction of methyl α-bromoacetate with cephalotaxyl pyruvate (16) obtained by esterification of cephalotaxine with acid chloride derived from 15.The preparations of 2 and its unsaturated derivative 13 are described in detail.Possible explanations of the steric requirements in the esterification of cephalotaxine and of the steric outcome of the Reformatsky reaction leading to 2 and 13 are advanced.