626250-22-4Relevant academic research and scientific papers
PROCESS FOR PREPARING OPTICALLY PURE 3-HYDROXY-PYRROLIDINE
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Page/Page column 11-13, (2008/06/13)
The present invention relates to a method for preparing optically pure 3-hydroxy-pyrrolidine, more particularly to a novel method for preparing 3-hydroxy-pyrrolidine economically, conveniently and efficiently, by reacting optically active 3,4-epoxy-1-butanol with ammonia and an aldehyde compound to prepare 4-protected-imino-butane-1,3-diol, selectively activating a hydroxy group at C-1 and then converting an imino group to an amine group by acid simultaneously or consecutively and performing intramolecular cyclization in the presence of a base.
