62645-28-7 Usage
Uses
Used in Pharmaceutical Industry:
RO 106-9920 is used as an anti-inflammatory agent for its ability to inhibit the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. This makes it a potential candidate for the treatment of inflammatory conditions.
Used in Respiratory Disease Treatment:
In the field of respiratory medicine, RO 106-9920 is used as an inhibitor to reduce mucin production in in vitro models of Chronic Obstructive Pulmonary Disease (COPD), suggesting its potential utility in managing this condition.
Used in Cancer Research:
RO 106-9920 is utilized as a research tool in cancer biology due to its weak inhibition of EGFR, 5-lipoxygenase, and iNOS. This property allows it to be used in studying the roles of these targets in cancer development and progression.
Used in Inflammation and Immune Response Studies:
RO 106-9920 serves as a valuable compound in the study of inflammation and immune response, as it interferes with NF-κB activation, a key regulator of these processes. This application is particularly relevant in the fields of immunology and cell biology.
Biological Activity
Inhibitor of NF- κ B activation, possibly via selective inhibition of LPS- and TNF- α -induced I κ B α ubiquitination (IC 50 = 3 μ M). Blocks subsequent production of TNF- α , IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo . Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
Check Digit Verification of cas no
The CAS Registry Mumber 62645-28-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,6,4 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 62645-28:
(7*6)+(6*2)+(5*6)+(4*4)+(3*5)+(2*2)+(1*8)=127
127 % 10 = 7
So 62645-28-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H7N5OS/c16-17(8-4-2-1-3-5-8)10-7-6-9-11-13-14-15(9)12-10/h1-7H
