6265-24-3 Usage
Uses
Used in Pharmaceutical Synthesis:
(E)-3-(4-methoxyphenyl)-N-methyl-prop-2-enamide is used as a starting material for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and functional groups make it a versatile building block in the development of new drugs and molecules with potential therapeutic applications.
Used in Drug Discovery and Development:
Due to its potential biological activities and pharmacological properties, (E)-3-(4-methoxyphenyl)-N-methyl-prop-2-enamide is used as a valuable component in drug discovery and development. Researchers can leverage its chemical structure to design and create novel compounds with specific therapeutic targets, potentially leading to the development of new medications for various diseases and conditions.
Used in Chemical Research:
(E)-3-(4-methoxyphenyl)-N-methyl-prop-2-enamide is also utilized in chemical research to study the properties and reactivity of propenamide derivatives. This can contribute to a better understanding of the structure-activity relationships in this class of compounds and may lead to the discovery of new synthetic methods or applications in various chemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 6265-24-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,6 and 5 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6265-24:
(6*6)+(5*2)+(4*6)+(3*5)+(2*2)+(1*4)=93
93 % 10 = 3
So 6265-24-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO2/c1-12-11(13)8-5-9-3-6-10(14-2)7-4-9/h3-8H,1-2H3,(H,12,13)/b8-5+
6265-24-3Relevant academic research and scientific papers
Tandem superelectrophilic hydroarylation of CC bond and carbonyl reduction in cinnamides: Synthetic rout to 3,3-diarylpropylamines, valuable pharmaceuticals
Zakusilo, Dmitry N.,Ryabukhin, Dmitry S.,Boyarskaya, Irina A.,Yuzikhin, Oleg S.,Vasilyev, Aleksander V.
, p. 102 - 108 (2015/02/02)
Cinnamides ArCHCHCONRR′ in reactions with arenes Ar′H under the action of Bronsted (TfOH, FSO3H) or Lewis (AlBr3) superacids at rt for 1-2 h give CC bond hydroarylation products ArAr′CHCH2CONRR′ in yields of 63-98%. Reduction (LiAlH4/Et2O) of carbonyl group in the latter results in the formation of 3,3-diarylpropylamines ArAr′CHCH2CH2NRR′, valuable drugs. The reaction intermediates, superelectrophilic dications ArC+H-CH2C(OH+)NRR′, have been characterized by DFT calculations in terms of global electrophilicity index, natural charges, and atomic orbitals contributions.
Metal-free tandem oxidative aryl migration and C-C bond cleavage: Synthesis of α-ketoamides and esters from acrylic derivatives
Liu, Le,Du, Liang,Zhang-Negrerie, Daisy,Du, Yunfei,Zhao, Kang
supporting information, p. 5772 - 5775 (2015/02/19)
A novel tandem metal-free oxidative aryl migration/C-C bond-cleavage reaction, mediated by hypervalent iodine reagent, has been discovered. The presented transformation provided straightforward access to important α-ketoamide and α-ketoester derivatives from readily available acrylic derivatives via a concerted process of 1,2-aryl shift concomitant with C-C bond cleavage.
