6266-09-7

Usage

Chemical class

Benzimidazole derivatives
A class of chemical compounds that includes 2-(2-Hydroxyphenyl)-5-methyl-1H-benzimidazole.

Structure

Heterocyclic aromatic compound
Consists of a benzene ring fused to an imidazole ring, contributing to its aromatic properties.

Functional groups

Hydroxyphenyl and methyl groups
A hydroxyphenyl group is attached to the second carbon of the imidazole ring, while a methyl group is at the fifth position.

Pharmacological activities

Anti-cancer, anti-inflammatory, and anti-viral properties
Benzimidazoles, including 2-(2-Hydroxyphenyl)-5-methyl-1H-benzimidazole, are known for their diverse range of pharmacological activities, which can be further studied for potential use in pharmaceutical and medical applications.

Specific properties and activities

Dependent on chemical structure
The properties and activities of 2-(2-Hydroxyphenyl)-5-methyl-1H-benzimidazole are influenced by its unique chemical structure, which can be analyzed to determine its potential applications in the pharmaceutical and medical fields.

InChI:InChI=1/C14H12N2O/c1-9-6-7-11-12(8-9)16-14(15-11)10-4-2-3-5-13(10)17/h2-8,15-16H,1H3/b14-10-

Upstream product

• 496-72-0 4-methyl-1,2-diaminobenzene 
• 74405-11-1 4-Chloro-2,2-diethyl-2H-benzo[e][1,3]oxazine 
• 90-02-8 salicylaldehyde 
• 69-72-7 salicylic acid 
• 65-45-2 salicylamide 
• 77773-92-3 2,3-Dihydro-2,2-diethyl-4H-1,3-benzoxazin-4-one 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 104620-02-2 1-[4-Hydroxy-3-(5-methyl-1H-benzoimidazol-2-yl)-phenyl]-nonan-1-one 
• 104620-01-1 1-[4-Hydroxy-3-(5-methyl-1H-benzoimidazol-2-yl)-phenyl]-octan-1-one 
• 104620-00-0 1-[4-Hydroxy-3-(5-methyl-1H-benzoimidazol-2-yl)-phenyl]-heptan-1-one 

Relevant academic research and scientific papers

Synthesis and evaluation of 2-aryl-1H-benzo[d]imidazole derivatives as potential microtubule targeting agents

Microtubule targeting agents (MTAs) are the potential drug candidates for anticancer drug discovery. Disrupting the microtubule formation or inhibiting the de-polymerization process by a synthetic molecule can lead to an excellent anticancer drug candidat

A facile and efficient synthesis of benzimidazole as potential anticancer agents

Abstract: This study reports a simple process to synthesize and separate of 2-(substituted-phenyl) benzimidazole derivatives with high yield and efficiency. Specifically, by reacting ortho-phenylenediamines with benzaldehydes using sodium metabisulphite a

Complexes containing benzimidazolyl-phenol ligands and Ln(III) ions: Synthesis, spectroscopic studies and preliminary cytotoxicity evaluation

Fourteen new complexes were obtained from Ln(III)(NO3)3?n-H2O and the chromophores 2-(1H-benzo[d]imidazol-2-yl)-phenol (Bzp1) or 2-(5-methyl-1H-benzo[d]imidazol-2-yl)-phenol (Bzp2). The complete characterization allowed us

Synthesis and characterization of Ni(II) complexes bearing of 2-(1H–benzimidazol-2-yl)-phenol derivatives as highly active catalysts for ethylene oligomerization

Novel Ni(II) complexes of 2-(1H–benzimidazol-2-yl)-phenol derivatives (HLx: x = 1–5; C1–C5) have been synthesized and characterized. In the mononuclear complexes, the ligands were coordinated as bidentate, via one imine nitrogen and the phenola

Preparation, characterization, DFT calculations and ethylene oligomerization studies of iron(II) complexes bearing 2-(1H-benzimidazol-2-yl)-phenol derivatives

Five 2-(1H-benzimidazol-2-yl)-phenol derivatives including 1H (HL1), 5-chloro-(HL2), 5-methyl-(HL3), 5,6-dichloro-(HL4), and 5,6-dimethyl-(HL5) were synthesized by the reaction of their corresponding

6,7-Dihydrobenzo[f]benzo[4,5]imidazo[1,2-d][1,4]oxazepine derivatives as selective inhibitors of PI3Kα

Twenty eight 6,7-dihydrobenzo[f]benzo[4,5]imidazo[1,2-d][1,4]oxazepine derivatives were synthesized and evaluated their biological activities as PI3K inhibitors. Biological evaluation against four human tumor cell lines revealed that most target compounds

DBSA mediated chemoselective synthesis of 2-substituted benzimidazoles in aqueous media

An efficient synthetic method has been developed for the facile synthesis of 2-substituted benzimidazoles in organized aqueous media in the presence of a surfactant (viz. DBSA) as catalyst and I2 as co-catalyst. The method described has the advantages of operational simplicity, excellent yields, high chemoselectivity, and clean and green reaction profile.

A simple and efficient one-pot synthesis of 2-substituted benzimidazoles

A simple and efficient procedure for the synthesis of substituted benzimidazoles through a one-pot condensation of o-phenylenediamines with aryl aldehydes in the presence of H2O2/HCl system in acetonitrile at room temperature is described. Short reaction time, large-scale synthesis, easy and quick isolation of the products, and excellent yields are the main advantages of this procedure. Georg Thieme Verlag Stuttgart.

Microwave-assisted one-pot synthesis of 2-(substituted phenyl)-1H- benzimidazole derivatives

A series of 2-(substituted phenyl)-1H-benzimidazole derivatives with various 5-and 6-position substituents (-H, -CH3, -CF3) were synthesized via microwave irradiation using a short synthetic route and Na2S2O5 as oxidant. This simple, fast, and efficient p

Synthesis and fluorescent properties of 2-(1H-benzimidazol-2-yl)-phenol derivatives

A high yield one pot synthesis of 2-(2-hydroxyaryl)-1H-benzimidazole derivatives by 2-hydroxy aromatic aldehydes with aromatic 1,2-diamines in the presence of manganese(III) acetate at room temperature was developed. Nine fluorescencers 2-(2-hydroxyaryl)-1H-benzimidazoles with substituent(s) X (X = H, CH3, CH3O, Cl) and two fluorescencers 2-(2-hydroxyaryl)-1H-naphth[2,3-d]imidazoles with substituent of H or Cl were prepared in 38-87% yield and the ultraviolet absorption and fluorescent spectra of the eleven compounds synthesized were measured in methanol. The fluorescent characteristics of the 2-(2-hydroxyaryl)benzimidazole derivatives prepared were investigated on the basis of excited-state intramolecular proton transfer mechanism, Stokes' shift, quantum yield, and the relationship between fluorescent intensity and the substituents were derived.