62663-25-6Relevant articles and documents
Design, synthesis and SAR of substituted indoles as selective TrkA inhibitors
Hurzy, Danielle M.,Henze, Darrell A.,Cabalu, Tamara D.,Narayan, Kartik,Heller, Amanda,Cooke, Andrew J.
, p. 2695 - 2701 (2017/05/29)
A series of substituted indoles were examined as selective inhibitors of tropomyosin-related kinase receptor A (TrkA), a therapeutic target for the treatment of pain. An SAR optimization campaign based on ALIS screening lead compound 1 is reported.
Novel indole α-methylene-γ-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases
Ding, Huasheng,Zhang, Chao,Wu, Xihan,Yang, Chunhao,Zhang, Xiongwen,Ding, Jian,Xie, Yuyuan
, p. 4799 - 4802 (2007/10/03)
In an effort to generate novel anticancer agents, a series of hybrids of α-methylene-γ-lactones and 2-phenyl indoles has been synthesized and evaluated for inhibition activities on the phosphorylation of AKT, mTOR, p70S6 kinase, and 4E-BP1. The results in
