65746-57-8Relevant academic research and scientific papers
New approach for the synthesis of N-indolyl ketones and aldehydes
Ding, Hua-Sheng,Yang, Chun-Hao,Xie, Yu-Yuan
, p. 2625 - 2632 (2007/10/03)
A new approach for the synthesis of N-indolyl ketones and aldehydes was developed. In the reaction of N-indolyl carboxylic acids with alkyl lithium, an interesting phenomenon appeared when using THF as solvent instead of ethyl ether. Copyright Taylor & Francis, Inc.
Novel indole α-methylene-γ-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases
Ding, Huasheng,Zhang, Chao,Wu, Xihan,Yang, Chunhao,Zhang, Xiongwen,Ding, Jian,Xie, Yuyuan
, p. 4799 - 4802 (2007/10/03)
In an effort to generate novel anticancer agents, a series of hybrids of α-methylene-γ-lactones and 2-phenyl indoles has been synthesized and evaluated for inhibition activities on the phosphorylation of AKT, mTOR, p70S6 kinase, and 4E-BP1. The results in
