62679-91-8Relevant academic research and scientific papers
ANALOGS OF PYRIMIDINE NUCLEOSIDES. 14. SYNTHESIS AND ANTITUMORIGENIC ACTIVITY OF ALKOXYALKYL DERIVATIVES OF 5-FLUOROURACIL
Karpeiskii, M. Ya.,Mikhailov, S. M.,Tsieminya, A. S.,Ziderman, A. A.,Kravchenko, I. M.,et al.
, p. 1176 - 1179 (2007/10/02)
A number of alkoxyalkyl derivatives of 5-fluorouracil were synthesized by alkylation of 2,4-bis(trimethylsilyl)-5-fluorouracil with α-chloro ethers or by the addition of 5-fluorouracil to vinyl ethers.It was established that the synthesized compounds are capable of increasing the lifetimes of mice with L-1210 leukemia and La hemocytoblastosis.The UV and NMR spectra of the synthesized compounds are presented.
