6269-51-8

Basic information

• Product Name: methyl 3-[4-(4-chlorophenyl)piperazin-1-yl]propanoate
• CAS NO: 6269-51-8
• Molecular Formula: C₁₄H₁₉ClN₂O₂
• Molecular Weight: 282.7659
• Mol File: 6269-51-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 405.4°C at 760 mmHg
• Flash Point: 199°C
• Density: 1.184g/cm³
• Vapor Pressure: 8.8E-07mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: methyl 3-[4-(4-chlorophenyl)piperazin-1-yl]propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-[4-(4-chlorophenyl)piperazin-1-yl]propanoate(6269-51-8)
• EPA Substance Registry System: methyl 3-[4-(4-chlorophenyl)piperazin-1-yl]propanoate(6269-51-8)

Safety Data

• Hazardous Substances Data: 6269-51-8(Hazardous Substances Data)

Upstream product

• 38212-33-8 4-(4-chlorophenyl) piperazine 
• 292638-85-8 acrylic acid methyl ester 

Relevant articles and documents

Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease

In this study, four series of compounds with benzoxazolone and benzothiazolone cores were designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease (AD). Additionally, in order to shed light on the effect of the carbonyl groups of benzoxazolone/benzothiazolone, benzoxazole/benzothiazole-containing analogues were also synthesized and evaluated. Inhibition potency of all final compounds towards cholinesterase enzymes and their antioxidant activity were tested. Subsequently, the anti-inflammatory activity, cytotoxicity, apoptosis, and Aβ aggregation inhibition tests were also performed for selected compounds. The results indicated that compounds 11c, a pentanamide derivative with benzothiazolone core, and 14b, a keton derivative with benzothiazolone core, were considered as promising multi-functional agents for further investigation against AD. The reversibility, kinetic and molecular docking studies were also performed for the compounds with the highest AChE 14b (eeAChE IC50 = 0.34 μM, huAChE IC50 = 0.46 μM) and BChE 11c (eqBChE IC50 = 2.98 μM, huBChE IC50 = 2.56 μM) inhibitory activities.