627-64-5

Usage

Uses

Used in Chemical Experiments:
Fumaramide is used as a reagent in chemical experiments for its ability to participate in various reactions, contributing to the understanding of chemical processes.
Used in Pharmaceutical Production:
Fumaramide is used as an intermediate in the synthesis of pharmaceuticals, aiding in the development of new drugs and medicines.
Used in Agriculture:
Fumaramide is used as a component in the production of agriculture-related products, such as pesticides and fertilizers, to improve crop yield and protect plants from pests.
Used in Research and Development:
Fumaramide is used as a research compound in the study of chemical reactions, helping scientists to explore new reaction pathways and develop innovative applications in various fields.

InChI:InChI=1/C4H6N2O2/c5-3(7)1-2-4(6)8/h1-2H,(H2,5,7)(H2,6,8)/b2-1-

Upstream product

• 763-51-9 diethyl 2-bromosuccinate 
• 764-42-1 butenedinitrile 
• 624-49-7 dimethylfumarate 
• 623-91-6 diethyl Fumarate 
• 141-05-9 Diethyl maleate 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 7722-84-1 dihydrogen peroxide 
• 764-42-1 1,2-Dicyanoethylene 
• 79-06-1 2-propenamide 
• 61530-27-6 azido-succinic acid diethyl ester 
• 928-01-8 maleamide 
• 6971-10-4 (E)-4-amino-4-oxo-2-butenoic acid methyl ester 

Downstream Products

• 764-42-1 1,2-Dicyanoethylene 
• 5602-35-7 1,4-Endomethylen-cyclohex-5-en-trans-2,3-dicarbonsaeurediamid 

Relevant academic research and scientific papers

Bis(allyl)-ruthenium(IV) complexes with phosphinous acid ligands as catalysts for nitrile hydration reactions

Several mononuclear ruthenium(iv) complexes with phosphinous acid ligands [RuCl2(η3:η3-C10H16)(PR2OH)] have been synthesized (78-86% yield) by treatment of the dimeric precursor [{RuCl(μ-Cl)(η3:η3-C10H16)}2] (C10H16 = 2,7-dimethylocta-2,6-diene-1,8-diyl) with 2 equivalents of different aromatic, heteroaromatic and aliphatic secondary phosphine oxides R2P(O)H. The compounds [RuCl2(η3:η3-C10H16)(PR2OH)] could also be prepared, in similar yields, by hydrolysis of the P-Cl bond in the corresponding chlorophosphine-Ru(iv) derivatives [RuCl2(η3:η3-C10H16)(PR2Cl)]. In addition to NMR and IR data, the X-ray crystal structures of representative examples are discussed. Moreover, the catalytic behaviour of complexes [RuCl2(η3:η3-C10H16)(PR2OH)] has been investigated for the selective hydration of organonitriles in water. The best results were achieved with the complex [RuCl2(η3:η3-C10H16)(PMe2OH)], which proved to be active under mild conditions (60 °C), with low metal loadings (1 mol%), and showing good functional group tolerance.

Cross-metathesis assisted by microwave irradiation

Microwave irradiation effectively accelerates cross-coupling metathesis reactions between deactivated olefins. Reactions have been carried out with the phosphine-free Hoveyda-Grubbs catalyst and the "second generation Grubbs' catalyst." While there have been reports that a "microwave effect" is observed in various transformations, the accelerations we observe are due to the efficient and rapid heating and increased pressure in the microwave apparatus.