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4-(4-Methoxyphenyl)-1-(4-pyridylcarbonyl)semicarbazide is a chemical compound with the molecular formula C13H14N4O3. It is a derivative of semicarbazide, featuring a 4-methoxyphenyl group and a 4-pyridylcarbonyl group attached to the semicarbazide core. 4-(4-METHOXYPHENYL)-1-(4-PYRIDYLCARBONYL)SEMICARBAZIDE is known for its potential applications in the synthesis of pharmaceuticals and agrochemicals, particularly as an intermediate in the preparation of various biologically active molecules. Its structure allows for the formation of hydrogen bonds and other interactions, which can be exploited in drug design to enhance binding affinity and selectivity. The compound is typically synthesized through a condensation reaction involving the appropriate amines and carbonyl compounds, and its properties can be further explored for the development of new therapeutic agents or chemical tools.

6270-66-2

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6270-66-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6270-66-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,7 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6270-66:
(6*6)+(5*2)+(4*7)+(3*0)+(2*6)+(1*6)=92
92 % 10 = 2
So 6270-66-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H14N4O3/c1-21-12-4-2-11(3-5-12)16-14(20)18-17-13(19)10-6-8-15-9-7-10/h2-9H,1H3,(H,17,19)(H2,16,18,20)

6270-66-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-methoxyphenyl)-3-(pyridine-4-carbonylamino)urea

1.2 Other means of identification

Product number -
Other names 4-(4-METHOXYPHENYL)-1-(4-PYRIDYLCARBONYL)SEMICARBAZIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6270-66-2 SDS

6270-66-2Relevant academic research and scientific papers

N-substituted 2-isonicotinoylhydrazinecarboxamides-new antimycobacterial active molecules

Rychtarcikova, Zuzana,Kratky, Martin,Gazvoda, Martin,Komloova, Marketa,Polanc, Slovenko,Kocevar, Marijan,Stolarikova, Jirina,Vinsova, Jarmila

, p. 3851 - 3868 (2014/05/20)

This report presents a new modification of the isoniazid (INH) structure linked with different anilines via a carbonyl group obtained by two synthetic procedures and with N-substituted 5-(pyridine-4-yl)-1,3,4-oxadiazole-2-amines prepared by their cyclisation. All synthesised derivatives were characterised by IR, NMR, MS and elemental analyses and were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv, Mycobacterium avium 330/88, Mycobacterium kansasii 235/80 and one clinical isolated strain of M. kansasii 6509/96. 2-Isonicotinoyl-N-(4- octylphenyl)hydrazinecarboxamide displayed an in vitro efficacy comparable to that of INH for M. tuberculosis with minimum inhibitory concentrations (MICs) of 1-2 μM. Among the halogenated derivatives, the best anti-tuberculosis activity was found for 2-isonicotinoyl-N-(2,4,6-trichlorophenyl) hydrazinecarboxamide (MIC = 4 μM). In silico modelling on the enoyl-acyl carrier protein reductase InhA confirmed that longer alkyl substituents are advantageous for the interactions and affinity to InhA. Most of the hydrazinecarboxamides, especially those derived from 4-alkylanilines, exhibited significant activity against INH-resistant nontuberculous mycobacteria. gfjh+l;kfldf.

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