627064-69-1Relevant academic research and scientific papers
Fast and chemoselective N-debenzylation route to chiral 2-substituted thiomorpholin-3-ones
Franceschini, Nicolas,Da Nascimento, Sophie,Miel, Hugues,Sonnet, Pascal
, p. 509 - 512 (2005)
Reaction time was found to be the critical parameter for the chemoselective N-debenzylation of thiomorpholin-3-one-derivatives with lithium in ammonia. This paper also reports the first preparation of a chiral 2-substituted thiomorpholine building block.
Efficient enantioselective synthesis of 2-substituted thiomorpholin-3-ones
Franceschini, Nicolas,Da Nascimento, Sophie,Sonnet, Pascal,Guillaume, Dominique
, p. 3401 - 3405 (2007/10/03)
The synthesis of enantiomerically pure 4-(2-hydroxy-(1R)-phenylethyl)- thiomorpholin-3-one 2 from (R)-phenylglycine methyl ester, S-benzylthioglycolic acid and bromoacetic acid is reported. Stereoselective C-2 alkylation of 2, performed using various elec
