627086-17-3Relevant academic research and scientific papers
Carbene induced rearrangement products from two furoquinolinone scaffolds
Lindahl, Karl-Fredrik,Carroll, Anthony,Quinn, Ronald J.,Ripper, Justin A.
experimental part, p. 998 - 1003 (2010/09/03)
(Chemical Equation Presented) Novel double CH-insertion and rearrangement products (5, 6, and 7) were isolated from treatment of 1 or 2 with dimethyl diazomalonate (3) under dirhodiumtetrakis mediated carbenoid chemistry conditions. A new possible reaction pathway is suggested and discussed. Also other diazo compounds were tested.
Synthesis and anticancer evaluation of certain 4-anilinofuro[2,3-b] quinoline and 4-anilinofuro[3,2-c]quinoline derivatives
Chen, Yeh-Long,Chen, I.-Li,Wang, Tai-Chi,Han, Chein-Hwa,Tzeng, Cherng-Chyi
, p. 928 - 934 (2007/10/03)
Certain linear 4-anilinofuro[2,3-b]quinoline and angular 4-anilinofuro[3,2-c]quinoline derivatives were synthesized and evaluated in vitro against the full panel of NCI's 60 cancer cell lines. For the linear 4-anilinofuro[2,3-b]quinoline derivatives, 1-[4-(furo[2,3-b]quinolin-4-ylamino) phenyl]ethanone (5a) is the most cytotoxic with a mean GI50 value of 0.025 μM. Substitution at either furo[2,3-b]quinoline ring (2a, 2b, and 5b) or 4-anilino moiety (3-7) led to a decrease of cytotoxicity. For the angular 4-anilinofuro[3,2-c]quinoline derivatives, (E)-1-[3-(furo[3,2-c]quinolin-4- ylamino)phenyl]ethanone oxime (14a) exhibited potent inhibitory activities on UO-31, UACC-257, and UACC-62, with GI50 values of 0.03, 50 values against UO-31, UACC-257, and UACC-62 was 50 value of 7.73 and 8.91 μM respectively.
4-anilinofuro [3,2-c] quinoline derivatives, and preparation processes and uses of the same
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Page column 14, (2010/02/05)
Disclosed herein are novel 4-anilinofuro[3,2-c]quinoline derivatives of formula (I): wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation process of these derivatives, an
