627105-66-2

Upstream product

• 31165-67-0 2'-benzyloxyacetophenone 
• 118-93-4 o-hydroxyacetophenone 
• 577-16-2 2-Methylacetophenone 
• 150982-69-7 2-(2-bromomethyl-phenyl)-2-methyl-[1,3]dioxolane 
• 150982-68-6 2-methyl-2-(2-methylphenyl)-1,3-dioxolane 
• 100-44-7 benzyl chloride 
• 627105-64-0 (+/-)-1-(2-benzyloxyphenyl)-ethanethiol 
• 94001-66-8 1-(2-benzyloxyphenyl)-1-ethanol 
• 627105-65-1 (+/-)-2-{2-[1-(2-benzyloxyphenyl)-ethylsulfanylmethyl]-phenyl}-2-methyl-[1,3]dioxolane 

Downstream Products

• 627105-69-5 (+/-)-1-{2-[1-(2-benzyloxyphenyl)-ethanesulfonylmethyl]-phenyl}-ethanol 
• 850465-53-1 (+/-)-1-(2-benzyloxyphenyl)-ethylsulfonylmethyl-[2-(1-methoxyethyl)]-phenyl 
• 627105-68-4 (+/-)-1-{2-[1-(2-benzyloxyphenyl)-ethanesulfonylmethyl]-phenyl}-ethanone 
• 627105-67-3 2-{2-[(E)-2-(2-Benzyloxy-phenyl)-propenyl]-phenyl}-2-methyl-[1,3]dioxolane 

Relevant academic research and scientific papers

Unexpected Z-stereoselectivity in the Ramberg-Baecklund reaction of diarylsulfones leading to cis-stilbenes: The effect of aryl substituants and application in the synthesis of the integrastatin nucleus

With certain substituent patterns, benzyl benzyl sulfone systems have been found to give unexpectedly high Z-stereoselectivity (up to E : Z = 1 : 16) in the Meyers variant of the Ramberg-Baecklund reaction. A range of sulfones, bearing various aryl substi

Synthesis of the Integrastatin Nucleus Using the Ramberg - Baecklund Reaction

(Equation presented) The first synthesis of the tetracyclic nucleus of the Integrastatins, natural products that have been shown to selectively inhibit HIV-1 integrase, is reported. Key steps of this synthesis involve a novel cis-selective Ramberg-Baecklund reaction and an unusual Lewis acid-promoted cyclization step.