627105-67-3Relevant academic research and scientific papers
Synthesis of the Integrastatin Nucleus Using the Ramberg - Baecklund Reaction
Foot, Jonathan S.,Giblin, Gerard M. P.,Taylor, Richard J. K.
, p. 4441 - 4444 (2007/10/03)
(Equation presented) The first synthesis of the tetracyclic nucleus of the Integrastatins, natural products that have been shown to selectively inhibit HIV-1 integrase, is reported. Key steps of this synthesis involve a novel cis-selective Ramberg-Baecklund reaction and an unusual Lewis acid-promoted cyclization step.
