62715-28-0

Basic information

• Product Name: H-HIS(1-TRT)-OME HCL
• Synonyms: N-IM-TRITYL-L-HISTIDINE METHYL ESTER HYDROCHLORIDE;N-TAU-TRITYL-HISTIDINE METHYL ESTER HYDROCHLORIDE;(S)-2-AMINO-3-(1-TRITYL-1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER;HISTIDINE(1-TRT)-OME HCL;H-HIS(1-TRT)-OME HCL;H-HIS(T-TRT)-OME HCL;H-HIS(TRT)-OME HCL
• CAS NO: 62715-28-0
• Molecular Formula: C₂₆H₂₅N₃O₂
• Molecular Weight: 447.96
• Product Categories: Amino Acids and Derivatives;Amino Acid Derivatives
• Mol File: 62715-28-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 555.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 6.55±0.10(Predicted)
• CAS DataBase Reference: H-HIS(1-TRT)-OME HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-HIS(1-TRT)-OME HCL(62715-28-0)
• EPA Substance Registry System: H-HIS(1-TRT)-OME HCL(62715-28-0)

Safety Data

• Hazardous Substances Data: 62715-28-0(Hazardous Substances Data)

Usage

General Description

H-HIS(1-TRT)-OME HCL is a chemical compound consisting of a modified histidine molecule with a trityl (TRT) protecting group and a methoxy (OME) group, in the form of a hydrochloride salt. H-HIS(1-TRT)-OME HCL is often used in peptide synthesis and drug development. The trityl group protects the histidine side chain during chemical reactions, while the methoxy group serves as a modulator of hydrophobicity and solubility. The hydrochloride salt form of the compound can improve its stability and solubility in aqueous solutions. Overall, H-HIS(1-TRT)-OME HCL is a versatile building block for the creation of novel peptides and pharmaceutical compounds.

Upstream product

• 68262-63-5 N^α-benzyloxycarbonyl-N^im-triphenylmethyl-L-histidine methyl ester 
• 76-83-5 trityl chloride 
• 4467-54-3 l-histidine methyl ester dihydrochloride 
• 937801-67-7 methyl-N^α-(((9H-fluoren-9-yl)methoxy)carbonyl)-N^τ-trityl-L-histidinate 
• 14997-58-1 N-[(benzyloxy)carbonyl]-L-histidine 
• 1499-46-3 L-Histidine methyl ester 
• 71-00-1 L-histidine 
• 40917-50-8 1,N^α-bis-benzyloxycarbonyl-histidine methyl ester 
• 22888-57-9 2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-L-histidine methyl ester 

Downstream Products

• 937801-66-6 Fmoc-(His(Trt))2-OMe 
• 607376-87-4 (+)-Methyl (2S)-2-{(3S)-3-[(tert-butoxycarbonyl)amino]pyrrolidinyl}-3-(1-trityl-1H-imidazol-4-yl)Propanoate 
• 176970-13-1 [(S)-2-(tert-butoxycarbonyamino)butane-1 ,4-diyl dimethanesulfonate] 
• 176752-35-5 methyl (2S)-2-(benzylamino)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoate 

Relevant articles and documents

Self-healing response in supramolecular polymers based on reversible zinc-histidine interactions

Histidine-metal interactions are utilized in many biological materials as reinforcing crosslinks, and in particular, are believed to contribute as reversible crosslinks to the intrinsic self-recovery behavior of mussel byssal threads. In this contribution

Synthesis and x-ray absorption spectroscopy structural studies of Cu(I) complexes of HistidylHistidine peptides: The predominance of linear 2-coordinate geometry

Modified His-His dipeptides have been reacted with copper(I) salts to model active-site Cu ions bound by contiguous His residues in certain oxygen-activating copper proteins, as well as amyloid β-peptide. Chelation of copper(I) by these ligands affords linear, two-coordinate complexes as studied structurally by X-ray absorption spectroscopy. The complexes are robust toward oxidation, showing limited to no reactivity with O2, and they bind CO weakly. Reaction with a third ligand (N-methylimidazole) affords complexes with a markedly different structure (distorted T-shaped) and reactivity, binding CO and oxidizing rapidly upon exposure to dioxygen. Copyright

Basic peptides in bee venom, II. Synthesis of two pentapeptides from the sequence of the mast cell degrading peptide

-