62715-70-2Relevant academic research and scientific papers
TETRAZOLES. XXX. ACYLATION OF 5-SUBSTITUTED TETRAZOLES
Myznikov, Yu. E.,Koldobskii, G. I.,Ostrovskii, B. A.,Poplavskii, V. S.
, p. 1125 - 1128 (2007/10/02)
The acylation of 5-substituted tetrazoles with carboxylic acid chlorides and anhydrides gives rise to 2,5-disubstituted 1,3,4-oxadiazoles in high yields.The reaction goes without the addition of organic bases at 100-105 deg C.The acylation of 5-substituted tetrazoles in a two-phase organic solvent-water system in presence of tetrabutylammonium bromide yields N-acyltetrazoles, which are converted into 2,5-disubstituted 1,3,4-oxadiazoles on thermolysis.
