62718-61-0

Upstream product

• 141-82-2 malonic acid 
• 28785-06-0 4-n-propylbenzaldehyde 
• 1038997-26-0 (E)-n-butyl 3-(4-n-propylphenyl)acrylate 
• 103-65-1 phenylpropane 

Downstream Products

• 110683-42-6 (E)-3-(4-Propyl-phenyl)-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-acrylamide 
• 120681-09-6 (E)-3-(4-Propyl-phenyl)-acryloyl chloride 
• 162752-13-8 3-(4-propylphenyl)propanoic acid 
• 1038997-25-9 3-[(E)-3-(4-n-propylphenyl)-2-propenoyl]-2-thiazolidinethione 
• 1196690-91-1 C₁₂H₁₇NO₂ 
• 120680-79-7 3-Phenyl-2-[(E)-3-(4-propyl-phenyl)-acryloylamino]-propionic acid 

Relevant academic research and scientific papers

Phenylalanine aminomutase-catalyzed addition of ammonia to substituted cinnamic acids: A route to enantiopure α- and β-amino acids

(Chemical Equation Presented) An approach is described for the synthesis of aromatic α- and β-amino acids that uses phenylalanine aminomutase to catalyze a highly enantioselective addition of ammonia to substituted cinnamic acids. The reaction has a broad scope and yields substituted α- and β-phenylalanines with excellent enantiomeric excess. The regioselectivity of the conversion is determined by substituents present at the aromatic ring. A box model for the enzyme active site is proposed, derived from the influence of the hydrophobicity of substituents on the enzyme affinity toward various substrates.

Mass spectrometric screening of enantioselective Diels-Alder reactions

(Chemical Equation Presented) A rapid cat. scan: Mass spectrometric monitoring of reaction intermediates of the retro-Diels-Alder reaction has allowed the rapid screening of catalysts for enantioselective Diels-Alder reactions (see scheme). Copper catalysts as well as metal-free organocatalysts were tested. A protocol for the simultaneous screening of catalyst mixtures has also been developed, which offers new possibilities for high-throughput catalyst development.

PHENYLALKYLCARBOXYLIC ACID DELIVERY AGENTS

The present invention provides phenylalkylcarboxylic acid compounds and compositions containing such compounds which facilitate the delivery of biologically active agents.

The discovery and synthesis of novel adenosine receptor (A2A) antagonists

In high throughput screening of our file compounds, a novel structure 1 was identified as a potent A2A receptor antagonist with no selectivity over the A1 adenosine receptor. The structure-activity relationship investigation using 1 as a template lead to identification of a novel class of compounds as potent and selective antagonists of A2A adenosine receptor. Compound 26 was identified to be the most potent A2A receptor antagonist (Ki = 0.8 nM) with 100-fold selectivity over the A1 adenosine receptor.

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.