62724-83-8

Usage

InChI:InChI=1/C10H13NO3/c1-2-3-6-14-8-4-5-9(10(12)13)11-7-8/h4-5,7H,2-3,6H2,1H3,(H,12,13)

Upstream product

• 66933-05-9 5-n-Butoxy-2-hydroxymethylpyridin 
• 1121-78-4 5-Hydroxy-2-methylpyridine 
• 6940-49-4 3-Bromophthalide 
• 109-65-9 1-bromo-butane 
• 247042-72-4 5-hydroxypyridine-2-carboxylic acid benzhydryl ester 
• 98353-01-6 2-methyl-5-propoxypyridine 
• 88910-23-0 5-n-Butoxy-2-acetoxymethylpyridin 
• 88910-21-8 5-n-Butoxy-2-methylpyridin 

Relevant academic research and scientific papers

ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT

The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the de

ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT

The invention relates to aryl-substituted polycyclic amines of formula I, particularly bicyclic amines, and the physiologically acceptable salts and physiologically functional derivatives thereof, the symbols and radicals being defined as indicated in the description.

Substituted N-aryl heterocycles, process for their preparation and their use as medicaments

The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I in which the radicals have the stated meanings, the N-oxides and the physiologically tolerated salts thereof and process for the preparation thereof are described. The compounds are suitable for example as anorectic agents.

Antipruritic composition

An antipruritic composition for an oral medicine, injection, and external medicine, comprising an effective amount of a chelated zinc (e.g., zinc picolinate) as an antipruritic agent.

A Structural Study of Mesogenic p-Alkoxy-Benzoic and -Pyridinic Acids Using Spectroscopic Techniques and MNDO Calculations

In order to investigate the relation between molecular structure and liquid crystal properties, structural studies are carried out on three series of compounds: 6-alkoxynicotinic acids, 5-alkoxypicolinic acids, and 4-alkoxybenzoic acids, using IR and 1H NMR spectroscopy and MNDO semi-empirical calculations.Spectroscopic results prove that, whereas inter-molecular O-H bonds favor mesomorphism, inter- and intra-molecular N-H bonds obstruct it.MNDO results show that the type of mesophase is determined by the direction of the molecular dipole moment.

The preparation of Some 4- and 5-Substituted Pyridine-2-carboxylic Acids as Fusaric Acid Analogues.

In view of future studies on the structure-activity relationships involved in the inhibition of dopamine β-hydroxylase, the authors synthetized 5-substituted picolinic acids and 4-substituted fusaric acids selected by means of a random sampling procedure suited for small series.On this occasion, they succeeded in improving markedly the well-known synthesis of 5-nitropicolinic acid via a Rosenmund-v.Braun reaction with 2-bromo-5-nitropyridine. 5-Hydroxypicolinic acid which is easily accessible in the same way could be converted into 5-alkyloxypicolinic acids by reaction with alkyl halides in DMSO in the presence of silver oxide. 4-Substituted fusaric acids became accessible via 5-n-butyl-2-methyl-4-nitropyridine-N-oxide.

5-Alkoxy-picolinic esters and anti-hypertensive composition containing 5-alkoxy-picolinic esters

5-Alkoxy-picolinic esters represented by the formula (I): STR1 wherein R represents an alkyl group having 1 to 6 carbon atoms and R1 represents an unsubstituted phenyl group; a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms or an acetyl group; a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an alkoxyalkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an indanyl group; or an acyloxyalkyl group having the formula STR2 wherein R2 represents a hydrogen atom or a methyl group and R3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc., group), an alkoxy group having 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as chlorine, bromine, iodine, etc., atom) or an aralkyl group wherein the alkyl moiety has 1 to 3 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-alkoxy-picolinic esters, and anti-hypertensive compositions containing the 5-alkoxy-picolinic esters.

5-Alkoxy-picolinic acid calcium salts and anti-hypertensive composition containing 5-alkoxy-picolinic acid calcium salts and anti-hypertensive composition thereof

5-Alkoxy-picolinic acids and the salts and the esters thereof represented by the formula (I): STR1 wherein R represents an alkyl group having 1 to 6 carbon atoms and M represents a hydrogen atom; a calcium atom; a sodium atom; a potassium atom; an aluminum atom; an unsubstituted phenyl group; a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as a chlorine, bromine, iodine, etc., atom); a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; or an acyloxyalkyl group having the formula STR2 wherein R2 represents a hydrogen atom or a methyl group and R3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc., group), an alkoxy group having 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as a chlorine, bromine, iodine, etc., atom) or an aralkyl group wherein the alkyl moiety has 1 to 3 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-alkoxy-picolinic acids and the salts and the esters thereof, and anti-hypertensive compositions containing the 5-alkoxy-picolinic acids and the salts and the esters thereof.