6273-42-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-chlorophenyl)-4-nitro-3-phenylbutan-1-one is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block in the development of new drugs.
Used in Agrochemical Industry:
1-(4-chlorophenyl)-4-nitro-3-phenylbutan-1-one is used as a reagent in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties allow for the creation of effective compounds for agricultural applications.
Used in Organic Synthesis:
1-(4-chlorophenyl)-4-nitro-3-phenylbutan-1-one is used as a reagent in organic synthesis, where it can be employed to produce a variety of organic compounds with different functional groups and applications. Its versatility in chemical reactions makes it a useful tool in the synthesis of complex molecules.

Upstream product

• 102-96-5 (2-nitroethenyl)benzene 
• 18931-60-7 1-(4-chlorophenyl)-4,4,4-trifluorobutane-1,3-dione 
• 75-52-5 nitromethane 
• 22966-22-9 (E)-1-(4-chlorophenyl)-3-phenyl-2-propen-1-one 
• 873-73-4 4-n-chlorophenylacetylene 
• 5153-67-3 nitrostyrene 
• 956-02-5 4'-chlorochalcone 

Downstream Products

• 1364952-19-1 2-(4-chlorophenyl)-4-phenyl-1H-pyrrole 
• 917871-33-1 5-(4-chlorophenyl)-3-phenyl-3,4-dihydro-2H-pyrrole 
• 861293-43-8 4-bromo-1-(4-chloro-phenyl)-3-nitro-4-phenyl-butan-1-one 
• 5347-27-3 (4-chloro-phenyl)-(2-nitro-3-phenyl-cyclopropyl)-ketone 
• 861382-49-2 4-benzyl-6-(4-chloro-phenyl)-2-oxo-2H-pyran-3-carboxylic acid methyl ester 
• 861382-51-6 4-benzyl-6-(4-chloro-phenyl)-2-oxo-2H-pyran-3-carboxylic acid 
• 119492-84-1 2-phenyl-5-(p-chlorophenyl)furan 
• 6289-89-0 2-bromo-1-(4-chloro-phenyl)-4-nitro-3-phenyl-butan-1-one 

Relevant academic research and scientific papers

A novel synthesis of γ-nitro ketones via detrifluoroacetylative Michael addition of 1-trifluoromethyl-1,3-diketones to conjugated nitroalkenes

A novel synthesis of γ-nitro ketones via detrifluoroacetylative Michael addition of 1-trifluoromethyl-1,3-diketones to conjugated nitroalkenes in the presence of sodium acetate in ethanol at room temperature is developed. A series of trifluoromethylated 1

Henry reaction and 1,4-addition of nitroalkanes to α,β- unsaturated carbonyl compounds under the influence of MS 4 A in DMSO

In the presence of MS 4 A in DMSO (dimethyl sulfoxide), Henry reaction with various carbonyl compounds and nitroalkanes proceeded smoothly to give the corresponding β-nitroalcohol without a base catalyst. Moreover, 1,4-additon of nitroalkane to α,β-unsaturated ketones was also performed in DMSO. Copyright

New synthesis of 1,3-diaryl-4-nitro-1-butanones by microwave-promoted Michael addition of nitromethane to chalcones without solvent

The Michael addition of nitromethane to chalcones promoted by microwave irradiation without solvent afforded 1,3-diaryl-4-nitro-1-butanones in good yield. The products were characterised by IR, 1H NMR and elemental analysis.

One-pot synthesis of substituted Δ1-pyrrolines through the Michael addition of nitroalkanes to chalcones and subsequent reductive cyclization in aqueous media

A facile and efficient one-pot synthesis of substituted Δ1-pyrrolines in aqueous media has been developed. Upon treatment with aqueous sodium hydroxide in N,N-dimethylformamide, a range of chalcones underwent room temperature Michael addition r

Enamines in solid-phase: Synthesis and reactivity towards electrophiles

Enamines are synthesized in solid-phase by amination of terminal, acetylenes with a secondary amine attached to Wang resin in a process catalyzed by mercury (II) acetate. The enamines obtained react with electrophiles such as isocyanates and nitroolefins to give rise to the expected addition products, which can be released from the resin by hydrolysis of the enamine under mild acidic conditions. (C) 2000 Elsevier Science Ltd.

Michael Additions Catalyzed by Metal(II) Complexes

Michael-addition reactions have been found to proceed in the presence of the Ni(OAc)2 or Co(OAc)2-2,2'-bypiridine complex in DMF under neutral conditions at room temperature without any by-product.The reactions of chalcone and its derivatives with nitromethane generally gave good results.The effects of metal(II) ions, ligands, counter ions, and solvents on the catalysis were examined, and the features of the metal-complex-catalyzed Michael reactions were studied, with some considerations also being given to the catalysis mechanism.

MICHAEL ADDITIONS CATALYZED BY NICKEL(II) OR COBALT(II)ACETATE-2,2'-BIPYRIDINE COMPLEXES

In the presence of nickel(II) or cobalt(II)acetate-2,2'-bipyridine complexes, α,β-unsaturated ketones, methyl acrylate, and acrylonitrile were found to react with nitromethane, malononitrile, and aniline at room temperature under neutral condition to afford addition products in good yields.