956-02-5

Basic information

• Product Name: 4'-Chlorochalcone
• Synonyms: BENZILIDENE-4-CHLOROACETOPHENONE;(E)-1-(4-CHLOROPHENYL)-3-PHENYLPROP-2-EN-1-ONE;1-(4-CHLOROPHENYL)-3-PHENYL-2-PROPEN-1-ONE;Benzylidene(4-chloroacetophenone);Ketone, p-chlorophenyl styryl;4'-Chlorochalcone;4-Chlorophenylstyryl ketone;Styryl 4-chlorophenyl ketone
• CAS NO: 956-02-5
• Molecular Formula: C₁₅H₁₁ClO
• Molecular Weight: 242.7
• EINECS: -0
• Product Categories: Chalcones;C15 to C38;Carbonyl Compounds;Ketones
• Mol File: 956-02-5.mol
• Article Data: 123

Chemical Properties

• Melting Point: 97-101 °C(lit.)
• Boiling Point: 386.8 °C at 760 mmHg
• Flash Point: 212 °C
• Appearance: /
• Density: 1.203 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 642281
• CAS DataBase Reference: 4'-Chlorochalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Chlorochalcone(956-02-5)
• EPA Substance Registry System: 4'-Chlorochalcone(956-02-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37
• WGK Germany: 3
• RTECS: UD5572990
• Hazardous Substances Data: 956-02-5(Hazardous Substances Data)

Usage

General Description

4'-Chlorochalcone is a chemical compound that belongs to the chalcone group and is also known as 4-chloro-1,3-diphenyl-2-propen-1-one. It is a yellow solid with a characteristic odor and is insoluble in water but soluble in organic solvents. 4'-Chlorochalcone has been studied for its potential biological activities, including its anti-inflammatory, antioxidant, and anticancer properties. It has been found to inhibit the growth of cancer cells by inducing apoptosis and has also shown potential for use in the development of new pharmaceuticals. Additionally, 4'-Chlorochalcone has been investigated for its potential as a natural food preservative due to its antimicrobial properties. Overall, 4'-Chlorochalcone is a versatile chemical compound with various potential applications in the fields of medicine, pharmaceuticals, and food preservation.

Upstream product

• 141-97-9 ethyl acetoacetate 
• 6948-68-1 1-chloro-4-(3-phenyl-2-propen-1-yl)benzene 
• 99-91-2 para-chloroacetophenone 
• 100-51-6 benzyl alcohol 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 104-88-1 4-chlorobenzaldehyde 
• 98-86-2 acetophenone 
• 102-92-1 cinnamoyl chloride 
• 108-90-7 chlorobenzene 
• 100-42-5 styrene 
• 19710-56-6 hydroxycarbene 
• 1679-18-1 4-Chlorophenylboronic acid 
• 637-87-6 1-Chloro-4-iodobenzene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 861589-78-8 2-bromo-1-(4-chloro-phenyl)-3-(oxo-diphenyl-phosphoranyl)-3-phenyl-propan-1-one 
• 6273-45-6 4-(4-chlorophenyl)-4-oxo-2-phenylbutanenitrile 
• 94257-64-4 5-(4-chloro-phenyl)-2-cyano-5-oxo-3-phenyl-valeric acid methyl ester 
• 861320-18-5 [3-(4-chloro-phenyl)-3-oxo-1-phenyl-propyl]-phosphonic acid 
• 94384-02-8 1-(4-chloro-phenyl)-3-morpholin-4-yl-3-phenyl-propan-1-one 
• 68257-72-7 1-(4-chloro-phenyl)-4-(3-methyl-4-nitro-isoxazol-5-yl)-3-phenyl-butan-1-one 
• 55434-28-1 4-(4-chloro-phenyl)-2,6-diphenyl-6H-[1,3]thiazine 
• 95163-15-8 1-(4-chloro-phenyl)-4-nitro-3,4-diphenyl-butan-1-one 
• 25856-06-8 2,3-dibromo-1-(4-chloro-phenyl)-3-phenyl-propan-1-one 
• 134834-71-2 5-(4-Chloro-phenyl)-7-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine 
• 134834-77-8 5-(4-Chloro-phenyl)-7-phenyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine 
• 126827-48-3 2-(4-Chloro-phenyl)-4-phenyl-1,4-dihydro-benzo[4,5]imidazo[1,2-a]pyrimidine 
• 150356-87-9 7-(4-chlorophenyl)-2,3-dihydro-5-phenyl-2-thioxopyrido<2,3-d>pyrimidin-4(1H)-one 
• 133414-96-7 8-(4-Chloro-phenyl)-6-phenyl-8,9-dihydro-7H-tetrazolo[1,5-b][1,2,4]triazepine 

Relevant articles and documents

Selective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite

Earth abundant metals are much less expensive, promising, valuable metals and could be served as catalysts for the borrowing hydrogen reaction, dehydrogenation and heterocycles synthesis, instead of noble metals. The uniformly dispersed zinc composites were designed, synthesized and carefully characterized by means of XPS, EDS, TEM and XRD. The resulting zinc composite showed good catalytic activity for the N-alkylation of amines with amines, ketones with alcohols in water under base-free conditions, while unsaturated carbonyl compounds could also be synthesized by tuning the reaction conditions. Importantly, it was the first time to realize the synthesis of 2-aryl-1H-benzo[d]imidazole derivatives by using this zinc composite under green conditions. Meanwhile, this zinc catalyst could be easily recovered and reused for at least five times.

Iridium and copper supported on silicon dioxide as chemoselective catalysts for dehydrogenation and borrowing hydrogen reactions

High active ligand usually plays an important role during catalysis and synthesis chemistry. A new and efficient benzotriazole-pyridinyl-silane ligand (BPS) was designed, and the corresponding iridium and copper catalysts were synthesized and thoroughly characterized by means of EDS, TEM, and XPS. The resulting iridium composite revealed excellent catalytic activity for the reaction of tert-butanesulfinamide with benzyl alcohols, while copper catalyst could realize the synthesis of unsaturated carbonyl compounds through the reaction of benzyl alcohols with ketones. This provided an efficient method for selective synthesis of unsaturated carbonyl compounds from benzyl alcohols and ketones in high yields with good recovery performance.

Tuning the Product Selectivity of the α-Alkylation of Ketones with Primary Alcohols using Oxidized Titanium Nitride Photocatalysts and Visible Light

The direct α-alkylation of ketones with alcohol to synthesize important α-alkylated ketones and enones is an attractive procedure for C-C bond formation. High reaction temperatures are always needed for heterogeneous catalysis using non-noble metals, and switching product selectivity in one catalysis system remains a great challenge. In the present study, a visible-light-driven procedure for this reaction is proposed, using oxidized TiN photocatalysts under mild conditions, whereby the product selectivity can be well-tuned. Oxidized TiN photocatalysts with tunable surface N/O ratios were successfully synthesized through the facile and flexible thermal oxidation treatment of low-cost TiN nanopowder. The α-alkylation of acetophenone with benzyl alcohol to form the two important compounds chalcone and dihydrochalcone occurred even at room temperature and almost complete conversion was achieved at 100 °C under visible light. The proportion of the two products can be well-tuned by switching the surface N/O ratio of the synthesized photocatalysts. Visible light is demonstrated to affect the surface N/O ratio of the photocatalysts and contribute to tuning the product selectivity. Light intensity and action spectrum study proves that the generation of energetic charge carriers results in the observed activities under visible light, based on interband transitions of TiN or the ligand-to-metal charge transfer (LMCT) effect of the surface complex formed on TiO2. Thermal energy can be coupled with light energy within this photocatalytic system, which will facilitate the full use of solar energy. Different sequential reaction mechanisms on TiN and TiO2 are proposed to be responsible for the tunable product selectivity. The wide reaction scope, the fine conversion at a low light intensity, and the favorable reusability of photocatalysts prove the great application potential of this visible-light-driven procedure for the α-alkylation of ketones with primary alcohols.