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Purpurogallin tetramethyl ether, also known as 3,4,5,6-tetramethoxy-1,2-benzoquinone, is a chemical compound derived from purpurogallin, a naturally occurring polyphenol found in plants. It is a yellow crystalline solid with the molecular formula C10H12O6 and a molecular weight of 228.2 g/mol. purpurogallin tetramethyl ether is characterized by its four methoxy groups attached to the benzoquinone structure, which contribute to its stability and solubility in organic solvents. Purpurogallin tetramethyl ether has been studied for its potential antioxidant, anti-inflammatory, and anticancer properties, making it a subject of interest in pharmaceutical and chemical research.

6273-57-0

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6273-57-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6273-57-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,7 and 3 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6273-57:
(6*6)+(5*2)+(4*7)+(3*3)+(2*5)+(1*7)=100
100 % 10 = 0
So 6273-57-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H16O5/c1-17-10-7-5-6-9-8-11(18-2)14(19-3)15(20-4)12(9)13(10)16/h5-8H,1-4H3

6273-57-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,3,4,6-tetramethoxybenzo[7]annulen-5-one

1.2 Other means of identification

Product number -
Other names 2,3,4,6-tetramethoxy-benzocyclohepten-5-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6273-57-0 SDS

6273-57-0Relevant articles and documents

ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX

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Page/Page column 18; 19; 21, (2014/02/16)

Provided are compounds, compositions and methods for treating Toll-like receptor 1/2 complex (TLRI/2) related inflammatory disorders. Small molecules, based on the benzotropolone scaffold, capable of influencing downstream signaling are dislcosed as well as methods of making and modifying these molecules. Also provided are methods for treating a subject for a clinical condition associated with Toll? like receptor complex 1/2 activation, comprising administering to the subject an effective amount of a benzotropolone compound.

Synthesis and evaluation as potential anticancer agents of novel tetracyclic indenoquinoline derivatives

Chakrabarty, Shubhashis,Croft, Michael S.,Marko, Melissa G.,Moyna, Guillermo

, p. 1143 - 1149 (2013/03/28)

We report the synthesis and evaluation as potential anticancer agents of a series of tetracyclic indenoquinolines. The compounds, which are obtained through the photoisomerization of Diels-Alder adducts formed between purpurogallin derivatives and nitrosobenzene, have in vitro antiproliferative activities in the μM to nM range against breast (MCF-7), lung epithelial (A-549), and cervical (HeLa) adenocarcinoma cells. The cytotoxicities of several of the novel tetracycles are comparable to or better than that of camptothecin. A strong correlation between the activity of the compounds and their aromaticity and planarity was observed, suggesting a mode of action similar to that of topoisomerase poisons.

Discovery of small-molecule inhibitors of the TLR1/TLR2 complex

Cheng, Kui,Wang, Xiaohui,Zhang, Shuting,Yin, Hang

supporting information, p. 12246 - 12249 (2013/02/23)

An important regulator of innate immunity, the protein complex of Toll-like receptors 1 and 2 (TLR1/TLR2) provides an attractive target for the treatment of various immune disorders. The novel compound CU-CPT22 can compete with the binding of the specific lipoprotein ligand to TLR1/TLR2 (see picture) with high inhibitory activity and specificity. Repression of downstream signaling from TNF-α and IL-1β was also observed. Copyright

Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives

Khrizman, Alexander,Moulthrop, Jason S.,Little, Susan,Wharton, Hayley,Yardley, Vanessa,Moyna, Guillermo

, p. 4183 - 4186 (2008/03/11)

We describe the synthesis and protozoocidal evaluation of a series of diazabicycles based on benzotropolone ethers. Several of the compounds, which can be obtained through a high-yielding hetero Diels-Alder reaction using simple and readily available star

Synthesis and biological evaluation of O-alkylated tropolones and related α-ketohydroxy derivatives as ribonucleotide reductase inhibitors

Tamburlin-Thumin, Isabelle,Crozet, Michel P.,Barriere, Jean-Claude,Barreau, Michel,Riou, Jean-Francois,Lavelle, Francois

, p. 561 - 568 (2007/10/03)

A series of O-alkylated tropolones and related α-ketohydroxy compounds were evaluated for their biological activities and were shown to present an expected ribonucleotide reductase inhibition and cytotoxicity against some cancer cell lines but no antitubulin activity. Pharmacomodulation studies were realised to understand and enhance the observed activities. These original benzylic, heterocyclic and allylic compounds have been synthesised by a phase-transfer catalysed O-alkylation developed in our laboratories.

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