6273-95-6

Basic information

• Product Name: propyl 4-hydroxy-3-methoxybenzoate
• Synonyms: propyl 4-hydroxy-3-methoxybenzoate
• CAS NO: 6273-95-6
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.22646
• Mol File: 6273-95-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 328.9°C at 760 mmHg
• Flash Point: 124.8°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 9.6E-05mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: propyl 4-hydroxy-3-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: propyl 4-hydroxy-3-methoxybenzoate(6273-95-6)
• EPA Substance Registry System: propyl 4-hydroxy-3-methoxybenzoate(6273-95-6)

Safety Data

• Hazardous Substances Data: 6273-95-6(Hazardous Substances Data)

Usage

General Description

Propyl 4-hydroxy-3-methoxybenzoate is a chemical compound commonly known as propylparaben. It is a member of the paraben family, which are esters of para-hydroxybenzoic acid. Propyl 4-hydroxy-3-methoxybenzoate is used as a preservative in a variety of cosmetic and pharmaceutical products, including lotions, creams, and sunscreens. It helps to prevent the growth of bacteria and fungi, extending the shelf-life of these products. However, there has been some controversy surrounding the safety of parabens, with some studies suggesting potential health risks such as hormone disruption. As a result, there has been increasing interest in developing alternative preservatives for use in consumer products.

InChI:InChI=1/C11H14O4/c1-3-6-15-11(13)8-4-5-9(12)10(7-8)14-2/h4-5,7,12H,3,6H2,1-2H3

Upstream product

• 71-23-8 propan-1-ol 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 

Relevant articles and documents

Structure–activity relationships of vanillic acid ester analogs in inhibitory effect of antigen-mediated degranulation in rat basophilic leukemia RBL-2H3 cells

Methyl vanillate (1) showed strong degranulation inhibitory activity among vanillin derivatives tested. In order to find structure–activity relationships for developing anti-allergic agents with simple structures and potent activity, we synthesized several vanillic acid (VA) ester derivatives with C1–C4and C8alkyl chains and evaluated their degranulation inhibitory activities. The most active compound of VA ester derivatives was derivative 5 with a C4straight alkyl chain, and derivative 5 exhibited approximately three-fold greater inhibitory activity than that of 1. Moreover, we designed 8 types of analogs based on 5, and we found that the minimum structure for potent degranulation inhibitory activity requires direct connection of the butyl ester moiety on the benzene ring and at least one hydroxyl group on the benzene ring. Butyl meta or para hydroxyl benzoate (10 or 11) has a simpler structure than that of 5 and exhibited more potent degranulation inhibitory activity than that of 5.