6274-86-8Relevant academic research and scientific papers
Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives
Das, Sajal Kumar,Panda, Gautam,Chaturvedi, Vinita,Manju,Gaikwad, Anil K.,Sinha, Sudhir
, p. 5586 - 5589 (2008/03/14)
A new series of diarylmethylnapthyloxy ethylamines were synthesized by aminoalkylation of diarylmethylnaphthols which were obtained by Friedel-Crafts alkylation on 1- and 2-naphthols using diarylcarbinols as the alkylating agents. The title compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro and showed MIC in the range of 3.12-25 μg/ml.
BF3-promoted aromatic substitution of N-alkyl α-trifluoromethylated imine: Facile synthesis of 1-aryl-2,2,2-trifluoroethylamines
Gong, Yuefa,Kato, Katsuya,Kimoto, Hiroshi
, p. 2637 - 2645 (2007/10/03)
The aromatic substitution of three representative N-alkyl trifluoromethyl imines 1a-c (R: a, benzyl; b, benzhydryl; c, methyl), obtained from primary alkyl amines and trifluoroacetaldehyde ethyl hemiacetal, was used to investigate the preparation of 1-aryl-2,2,2-trifluoroethylamines. In the presence of BF3·OEt2, the reaction of imine 1 with various aromatic compounds proceeded smoothly at room temperature, giving N-alkyl-1-aryl-2,2,2-trifluoroethylamines in moderate-to-high yields. Moreover, successful regioselective removal of N-benzyl and N-benzhydryl groups was achieved by hydrolysis in hydrochloric acid or by palladium-catalyzed hydrogenolysis.
