62756-43-8

Basic information

• Product Name: 7-Hydroxyspiro[chromene-2,1'-cyclohexan]-4(3H)-one
• Synonyms: 7-Hydroxyspiro[chromene-2,1'-cyclohexan]-4(3H)-one;7-hydroxy-4-spiro[chroman-2,1'-cyclohexane]one;7-hydroxyspiro[chroman-2,1'-cyclohexane]-4-one;BB_NC-1792;7-hydroxyspiro[chroman-2,1'-cyclohexan]-4-one;7-hydroxy-3,4-dihydrospiro[1-benzopyran-2,1-cyclohexane]-4-one;7-hydroxy-3,4-dihydrospiro[1-benzopyran-2,1-cyclohexan]-4-one
• CAS NO: 62756-43-8
• Molecular Formula: C₁₄H₁₆O₃
• Molecular Weight: 232.27504
• Mol File: 62756-43-8.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Hydroxyspiro[chromene-2,1'-cyclohexan]-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Hydroxyspiro[chromene-2,1'-cyclohexan]-4(3H)-one(62756-43-8)
• EPA Substance Registry System: 7-Hydroxyspiro[chromene-2,1'-cyclohexan]-4(3H)-one(62756-43-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 62756-43-8(Hazardous Substances Data)

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 108-94-1 cyclohexanone 
• 123-75-1 pyrrolidine 
• 7731-02-4 N-cyclohexylpyrrolidine 
• 65490-08-6 2-hydroxy-4-(methoxymethoxy)acetophenone 
• 108-46-3 recorcinol 
• 1552-91-6 cyclohexylideneacetic acid 

Downstream Products

• 1426137-41-8 C₂₆H₃₃NO₄ 
• 1426137-40-7 C₂₄H₂₉NO₅ 
• 1426137-39-4 C₂₄H₂₉NO₅ 
• 1426137-38-3 C₂₄H₂₉NO₄ 
• 1426137-37-2 C₂₃H₂₇NO₄ 
• 1300594-10-8 7-(2-hydroxy-3-(4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one 
• 1300594-09-5 7-(2-hydroxy-3-(4-p-tolyl-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one 
• 1300594-08-4 7-(2-hydroxy-3-(4-phenyl-1H-1,2,3-triazol-1-yl)propoxy)spiro[chroman-2,1'-cyclohexan]-4-one 

Relevant articles and documents

A NEW AND EFFICIENT GENERAL METHOD FOR THE SYNTHESIS OF 2-SPIROBENZOPYRANS: FIRST SYNTHESIS OF CYCLIC ANALOGUES OF PRECOCENE I AND RELATED COMPOUNDS

A new synthesis of spirobenzopyran has been accomplished by Friedel-Crafts reaction of various m-dihydroxybenzenes and cycloalkylidene acetic acid in the presence of a Lewis acid.

Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives

On the basis of recently reported abyssinone II and olympicin A, a series of chemically modified flavonoid phytochemicals were synthesized and evaluated against Mycobacterium tuberculosis and a panel of Gram-positive and -negative bacterial pathogens. Some of the synthesized compounds exhibited good antibacterial activities against Gram-positive pathogens including methicillin resistant Staphylococcus aureus with minimum inhibitory concentration as low as 0.39 μg/mL. SAR analysis revealed that the 2-hydrophobic substituent and the 4-hydrogen bond donor/acceptor of the 4-chromanone scaffold together with the hydroxy groups at 5- and 7-positions enhanced antibacterial activities; the 2′,4′-dihydroxylated A ring and the lipophilic substituted B ring of chalcone derivatives were pharmacophoric elements for antibacterial activities. Mode of action studies performed on selected compounds revealed that they dissipated the bacterial membrane potential, resulting in the inhibition of macromolecular biosynthesis; further studies showed that selected compounds inhibited DNA topoisomerase IV, suggesting complex mechanisms of actions for compounds in this series.

Synthesis, structure, and estrogenic activity of 2- and 3-substituted 2,3-dihydro-4H-1-benzopyran-4-ones

Molecules with potent estrogenic activity are ~270 A3 hydrophobic structures that encompass two hydroxyls among which is at least one phenol. However, compounds with only one phenol or devoid of such a ring have been shown to enhance ERα-mediat