62760-09-2

Basic information

• Product Name: 3,5-Pyridinedicarboxylic acid, 2-(diethoxymethyl)-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 5-(2-ethoxyethyl) 3-ethyl ester
• CAS NO: 62760-09-2
• Molecular Formula: C25H34N2O9
• Molecular Weight: 506.553
• Mol File: 62760-09-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarboxylic acid, 2-(diethoxymethyl)-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 5-(2-ethoxyethyl) 3-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarboxylic acid, 2-(diethoxymethyl)-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 5-(2-ethoxyethyl) 3-ethyl ester(62760-09-2)
• EPA Substance Registry System: 3,5-Pyridinedicarboxylic acid, 2-(diethoxymethyl)-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 5-(2-ethoxyethyl) 3-ethyl ester(62760-09-2)

Safety Data

• Hazardous Substances Data: 62760-09-2(Hazardous Substances Data)

Upstream product

• 6963-40-2 acetoacetic acid-(2-ethoxyethyl)-ester 
• 142619-07-6 β-ethoxyethyl 2-(m-nitrobenzylidene)acetoacetate 
• 62759-80-2 3-amino-4,4-diethoxycrotonic acid ethyl ester 
• 62759-80-2 ethyl 4,4-diethoxy-3-aminocrotonate 
• 62760-08-1 2-(3-Nitrobenzyliden)acetessigsaeure-(2-ethoxyethyl)ester 

Downstream Products

• 62760-56-9 2-ethoxyethyl 2-cyano-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate 
• 62760-79-6 2-ethoxyethyl 3-ethoxycarbonyl-2-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate 
• 62760-34-3 2-ethoxyethyl 3-ethoxycarbonyl-2-formyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylate 

Relevant articles and documents

Studies on nilvadipine. II. Synthesis and structure-activity relationships of 2-hydroxymethyl- and 2-cyano-1,4-dihydropyridines containing heteroatom-substituted ester at the 5-position

The synthesis of new 2-hydroxymethyl- and 2-cyano-1,4-dihydropyridines possessing a heteroatom-substituted alkyl ester group at the 5-position of the nucleus is described. The esters were introduced via a suitable method selected from the modified Hantzsch method (method A), the hydrolysis of a chloroethyl ester obtained by method A (method B) or the replacement of the chlorine atom with various kinds of amino groups (method C). Hydroxymethyl and cyano groups at the 2-position were prepared in a similar manner to that described in a previous paper. The hypotensive activities of the compounds prepared in this paper were compared with the corresponding alkyl ester at the 5-position reported previously. It was found that N-benzylmethylaminoethyl esters, especially N-(4-chlorobenzyl)and N-(3,4-dichlorobenzyl)-N-methylaminoethyl esters, were suitable substituents at the 5-position of the 1,4-dihydropyridine nucleus and that these substituents were somewhat more effective for hypotensive activity than simple alkyl esters in a series of 2-hydroxymethyl-1,4-dihydropyridine derivatives. But it was found that the effect was reversed in a series of 2-cyano-1,4-dihydropyridine derivatives. Both of them were found to be inferior to nilvadipine (1c), accepted in clinical use for the treatment of hypertension.

6-Acyloryalkyl-1,4-dihydropyridine derivatives and a method of effecting vasodilation therewith

This invention relates to 1,4-dihydropyridine derivatives. More particularly, it relates to new 1,4-dihydropyridine derivatives thereof which have vasodilating and anti-hypertensive activity, to processes for the preparation thereof, and to pharmaceutical composition comprising the same for therapeutical treatment in cardiovascular diseases and hypertension in human being.