6963-40-2

Usage

Uses

Used in Paints and Coatings Industry:
2-Ethoxyethyl acetoacetate is used as a reactive diluent for the production of polyurethane coatings, enhancing the solubility and reactivity of the coating systems.
Used in Adhesives Industry:
It serves as a reactive diluent in the production of polyurethane adhesives, improving the adhesive's performance and bonding capabilities.
Used in Pharmaceutical Industry:
2-Ethoxyethyl acetoacetate is used as a synthetic intermediate in the synthesis of various pharmaceuticals, contributing to the development of new medications.
Used in Agrochemical Industry:
2-ethoxyethyl acetoacetate is utilized as a synthetic intermediate in the production of agrochemicals, aiding in the development of effective crop protection products.
Used in Fragrance Industry:
2-Ethoxyethyl acetoacetate is employed in the synthesis of fragrances, providing unique scents and enhancing the performance of perfumes and scented products.
Used in Coordination Chemistry:
It can act as a ligand in coordination chemistry, playing a role in the formation of coordination compounds and contributing to advances in this field.

InChI:InChI=1/C8H14O4/c1-3-11-4-5-12-8(10)6-7(2)9/h3-6H2,1-2H3

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 110-80-5 2-ethoxy-ethanol 

Downstream Products

• 52452-35-4 4-Ethoxy-2-oxo-6-p-tolyl-cyclohex-3-enecarboxylic acid 2-ethoxy-ethyl ester 
• 75530-27-7 3-Oxo-2-[1-(2-trifluoromethyl-phenyl)-meth-(E)-ylidene]-butyric acid 2-ethoxy-ethyl ester 
• 75206-26-7 2-[1-(2-Cyano-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-ethoxy-ethyl ester 
• 142619-07-6 β-ethoxyethyl 2-(m-nitrobenzylidene)acetoacetate 
• 62760-00-3 2-ethoxyethyl 2-methyl-4-(2-nitrophenyl)-5-ethoxycarbonyl-6-diethoxymethyl-1,4-dihydropyridine-3-carboxylate 
• 62760-08-1 2-(3-Nitrobenzyliden)acetessigsaeure-(2-ethoxyethyl)ester 
• 75535-92-1 2-Diethoxymethyl-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-(2-ethoxy-ethyl) ester 3-ethyl ester 
• 75206-35-8 4-(2-Cyano-phenyl)-2-diethoxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-(2-ethoxy-ethyl) ester 3-ethyl ester 
• 75530-91-5 2-Cyano-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-(2-ethoxy-ethyl) ester 3-ethyl ester 
• 75530-57-3 2-Formyl-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-(2-ethoxy-ethyl) ester 3-ethyl ester 
• 75206-46-1 2-Cyano-4-(2-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-(2-ethoxy-ethyl) ester 3-ethyl ester 
• 75206-41-6 4-(2-Cyano-phenyl)-2-formyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-(2-ethoxy-ethyl) ester 3-ethyl ester 
• 75206-50-7 4-(2-Cyano-phenyl)-2-hydroxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-(2-ethoxy-ethyl) ester 3-ethyl ester 
• 62760-09-2 2-ethoxyethyl 2-diethoxymethyl-3-ethoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate 

Relevant academic research and scientific papers

Synthesis and antihypertensive activities of new 1,4-dihydropyridine derivatives containing a nitrooxy moiety at the 3-ester position

The synthesis of a new series of dihydropyridines containing a nitrooxy moiety at the 3-ester position is described. The antihypertensive activity of the compounds was examined and compared with that of nifedipine; some of them were relatively potent. The structure-activity relationship is also discussed.

Studies on nilvadipine. II. Synthesis and structure-activity relationships of 2-hydroxymethyl- and 2-cyano-1,4-dihydropyridines containing heteroatom-substituted ester at the 5-position

The synthesis of new 2-hydroxymethyl- and 2-cyano-1,4-dihydropyridines possessing a heteroatom-substituted alkyl ester group at the 5-position of the nucleus is described. The esters were introduced via a suitable method selected from the modified Hantzsch method (method A), the hydrolysis of a chloroethyl ester obtained by method A (method B) or the replacement of the chlorine atom with various kinds of amino groups (method C). Hydroxymethyl and cyano groups at the 2-position were prepared in a similar manner to that described in a previous paper. The hypotensive activities of the compounds prepared in this paper were compared with the corresponding alkyl ester at the 5-position reported previously. It was found that N-benzylmethylaminoethyl esters, especially N-(4-chlorobenzyl)and N-(3,4-dichlorobenzyl)-N-methylaminoethyl esters, were suitable substituents at the 5-position of the 1,4-dihydropyridine nucleus and that these substituents were somewhat more effective for hypotensive activity than simple alkyl esters in a series of 2-hydroxymethyl-1,4-dihydropyridine derivatives. But it was found that the effect was reversed in a series of 2-cyano-1,4-dihydropyridine derivatives. Both of them were found to be inferior to nilvadipine (1c), accepted in clinical use for the treatment of hypertension.