6277-35-6

Usage

Uses

Used in Food Industry:
1-methyl-1,4-dihydropyrazine is used as a flavoring agent for imparting a roasted, nutty, and earthy aroma to various food products. Its characteristic scent is responsible for the aroma of roasted coffee and is also found in roasted nuts, cocoa, bread, and other baked goods.
Used in Perfume and Cosmetics Industry:
Due to its distinctive and pleasing scent, 1-methyl-1,4-dihydropyrazine is utilized in the production of perfumes and cosmetics, adding a unique fragrance to these products.
Safety Note:
It is important to handle 1-methyl-1,4-dihydropyrazine with care, as it can cause irritation to the eyes and skin upon contact. Proper safety measures should be taken during its use in various applications.

Upstream product

• 290-37-9 1,4-pyrazine 
• 74-88-4 methyl iodide 
• 2423-84-9 Pyrazin-N_.N'-dioxyd 
• 6890-38-6 2,5-dimethylpyrazine-N,N'-dioxide 

Downstream Products

• 100-48-1 pyridine-4-carbonitrile 
• 3978-81-2 4-tert-butylpyridine 
• 2961-47-9 4-(1-butylpentyl)pyridine 
• 939-23-1 p-phenylpyridine 

Relevant academic research and scientific papers

Improvement in efficiency of the electrocatalytic reduction of hydrogen peroxide by prussian blue produced from the [fe(CN)5(mpz)]2-complex

Hydrogen peroxide is one of the most important molecules in chemical signaling in living organisms. Because of this, its sensing is indispensable for the diagnosis of many diseases. Among the materials used for the detection and quantification of H2O2, Prussian Blue (Phas been highlighted due to its performance. Therefore, the search for alternatives or the improvement of PB performance is a challenge. In this context, our motivation was to evaluate how the ligand N-methylpyrazinium affects the structure and reactivity of Prussian Blue films produced from [Fe(CN)5(mpz)]2-(PB-mpz). Based on the results, it was possible to conclude that the ligand is coordinated to the complex inside the PB framework and consequently contributes to the generation of a noncrystalline structure. The ions contained in buffer solutions can react with Prussian Blue by binding to Fe3+ and breaking the structure. In addition, a PBmpz film in HCl/KCl showed higher sensitivity towards H2O2 than a PB film.

Ion aggregation of methylpyrazinium iodide and its derivatives in crystals and in solutions of nonpolar solvents

Aggregation of methylpyrazinium iodide and its derivatives in chloroform and dichloromethane solutions was studied by EAS and 1H NMR spectroscopy. The isopentylpyrazinium iodide ion quadruple formation constants in solutions were evaluated. For

Identification of N- or O-Alkylation of Aromatic Nitrogen Heterocycles and N-Oxides Using 1H–15N HMBC NMR Spectroscopy

A series of representative diazines and pyridine N-oxides were subjected to alkylation using several different alkylating agents. The 15N NMR chemical shifts (δN values) of the diazines, pyridine N-oxides and derived alkylation products were determined using 1H-15N HMBC NMR spectroscopy at natural 15N abundance. The changes in the 15N NMR chemical shifts (Δ(δN) values) that occurred on going from starting materials to products in these reactions were analyzed. N-alkylation of diazines resulted in large upfield shifts of the δN values of the alkylated nitrogen (of the order of 100 ppm or greater). While O-alkylation of pyridine N-oxides resulted in upfield shifts of the δN values of the N-(alkoxy)pyridinium nitrogen, the Δ(δN) values were of a much smaller magnitude (ca. –42 ppm) than those observed for N-alkylations of diazines. Nitrogen NMR spectroscopic data from the literature of relevance to alkylation of azines, diazines, azine N-oxides and diazine N-oxides was gathered together, and using this in tandem with our 15N NMR spectroscopic data, we have been able to corroborate our observations on the trends observed in the Δ(δN) values associated with N- and O-alkylation reactions of aromatic N-heterocycles and N-oxides. An analysis protocol that relies on synergistic evaluation of 1H-15N HMBC and 1H-13C HMBC NMR spectra has been developed that enables unambiguous diagnosis of the occurrence of N-alkylation of aromatic N-heterocycles and O-alkylation of aromatic N-oxides.

Iodide···π Interactions of Perhalogenated Quinoid Rings in Co-crystals with Organic Bases ?

First anion···π contacts with quinoid rings have been described in novel co-crystals of tetrabromo- and tetrachloroquinone with iodide salts of substituted N-methylpyridinium cations. In seven crystal structures of these co-crystals, a centrosymmetric unit I-···quinone···I- is observed involving close contacts between iodide anions and electron-depleted carbon skeletons of the quinoid rings. However, the salt with N-methyl-4-methylcarboxypyridinium base crystallizes in two polymorphs characterized by O=C···quinone···C=O interaction instead of I-···quinone···I- one. A possible charge transfer, suggested by the black color of the crystals, is probed by solid-state NMR and IR spectroscopies and analyzed by DFT calculations.

PREPARATION AND STRUCTURE ELUCIDATION OF SOME N-ALKYLPYRAZINIUM SALTS AND THEIR N-OXIDES

Several N4-alkylpyrazinium N-oxide salts were prepared in high yields by heating the corresponding pyrazine N1-oxides in the presence of alkylating reagent and solvent.The proton nmr data point to the quinoidal nature of these compounds.Pyrazine di-N-oxides deoxygenated rapidly under same reaction conditions to yield a mixture of N-alkylpyrazinium and N-alkylpyrazinium mono-N-oxide salts.Mechanism is proposed to account for these reductive deoxygenations of the pyrazine nucleus.

Effect of Added Sodium Iodide on Spectral and Thermodynamic Properties of Methiodides of Some Nitrogen Heteroaromatics in Dipolar Aprotic Solvents

The longest wavelength band of N-methylpyrazinium iodide and 4-cyano-N-ethylpyridinium iodide, which incidentally is a charge transfer (CT) band, has been studied in various solvents such as acetone, acetonitrile and methyl ethyl ketone at 25 deg C as a function of the concentration of added sodium iodide.The observed blue shift of the CT band with the increase in concentration of the added salt has been explained by considering a suitable model of solvation involving a change of structure of the local environment of the ion pair by the added salt.In addition to the blue shift it has been observed that the intensities of transitions increase with increase in the concentration of the added NaI and finally tend to limiting values, which are significantly higher than the values expected in view of the existence of equilibrium between free ions and ion pairs.These results are, however, consistent with the view that there exists an equilibrium between the two forms of ion pairs, viz. contact form and the solvent separated form, and the addition of NaI does affect the equilibrium between the two forms.Attempts have been made to calculate the associated thermodynamic parameters for different equilibria in solution.