62777-25-7

Usage

Uses

Used in Organic Synthesis:
L-2-AMINO-5-PHENYL-PENTANOIC ACID is utilized as a chiral auxiliary, playing a crucial role in the synthesis of enantiomerically pure compounds, which is vital for the production of pharmaceuticals and other specialty chemicals that require specific stereochemistry.
Used in Pharmaceutical Industry:
L-2-AMINO-5-PHENYL-PENTANOIC ACID serves as a building block in the synthesis of various pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications.
Used in Neurological Disorder Treatment:
L-2-AMINO-5-PHENYL-PENTANOIC ACID is under investigation for its potential use in treating neurological disorders, given its unique structural properties that may offer therapeutic benefits in managing such conditions.
Used in Inflammatory Disease Management:
L-2-AMINO-5-PHENYL-PENTANOIC ACID is also being studied for its possible application in the treatment of inflammatory diseases, where its specific characteristics might help in reducing inflammation and associated symptoms.

Upstream product

• 88768-11-0 2-oxo-5-phenylpentanoic acid 
• 121704-10-7 2-(2-Methoxy-acetylamino)-5-phenyl-pentanoic acid 
• 52161-76-9 (E,2S)-2-amino-5-phenyl-pent-4-enoic acid 
• 52161-73-6 2-acetylamino-2-(3-phenyl-propyl)malonic acid diethyl ester 
• 81867-09-6 ethyl 2-oxo-5-phenylpentanoate 
• 637-59-2 1-Bromo-3-phenylpropane 
• 852298-94-3 (S)-2-Azido-5-phenyl-pentanoic acid 
• 62732-55-2 2-Acetylamino-2-(3-phenyl-propyl)-malonic acid 
• 852298-85-2 (4S,5R)-1-((S)-2-Azido-5-phenyl-pentanoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 852298-77-2 (4S,5R)-1-((R)-2-Bromo-5-phenyl-pentanoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one 

Downstream Products

• 98628-27-4 2-tert-butoxycarbonylamino-5-phenyl-pentanoic acid 
• 666718-96-3 (1-formyl-4-phenyl-butyl)-carbamic acid tert-butyl ester 
• 666718-84-9 (1-hydroxymethyl-4-phenyl-butyl)-carbamic acid tert-butyl ester 
• 666719-11-5 (4-cyclohexyl-1-hydroxymethyl-butyl)-carbamic acid tert-butyl ester 
• 400886-12-6 (S)-2-Amino-5-phenyl-pentanoic acid allyl ester 
• 400886-08-0 (S)-2-[(S)-2-((S)-2-Amino-propionyloxy)-3-methyl-butyrylamino]-5-phenyl-pentanoic acid allyl ester 
• 400886-11-5 (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionyloxy)-3-methyl-butyrylamino]-5-phenyl-pentanoic acid allyl ester 
• 56072-96-9 AM-toxin II 
• 120679-15-4 Boc-Ser(Bzl)-Ala-Hmb-App-OH 
• 120679-17-6 Boc-Ser(Bzl)-Ala-Hmb-App-ONSu 
• 768366-81-0 (S)-2-(3-methyl-benzoylamino)-5-phenyl-pentanoic acid 
• 1352825-27-4 (S)-2-(5-methoxybenzofuran-2-carboxamido)-5-phenylpentanoic acid 
• 873329-61-4 C₁₄H₂₃NO₂Si 
• 87053-93-8 Boc-ΔAla-L-Ala-L-Hmb-L-App-NH2 

Relevant academic research and scientific papers

Synthesis method of multi-configuration long-chain phenyl amino acid compound

The invention relates to a method for synthesizing a multi-configuration long-chain phenyl amino acid compound. The method comprises the following steps: reacting a compound shown in a formula I witha compound shown in a formula II or an isomer thereof in

Effective synthesis of optically active 3-phenyl-3-(3-trifluoromethyl) diazirinyl bishomophenylalanine derivatives

Effective incorporation of phenyldiazirine moiety on the acyl residue of L- and D- glutamic acid by Friedel-Crafts reactions with triflic acid developed simple preparation of bishomophenylalanine (bhPhe) for aromatics, which added a

Controlling diastereoselectivity in the reactions of enantiomerically pure α-bromoacyl-imidazolidinones with nitrogen nucleophiles: Substitution reactions with retention or inversion of configuration

Diastereoselective substitution reactions of α-bromoacyl- imidazolidinones with nitrogen nucleophiles can be promoted with either retention or inversion of configuration by carrying out reactions under epimerising or non-epimerising conditions. The Royal Society of Chemistry 2005.

Inhibitors of cathepsin S

The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The pr

Kinetic Resolution of Unnatural and Rarely Occuring Amino Acids: Enantioselective Hydrolysis of N-Acyl Amino Acids Catalyzed by Acylase I

Acylase I (aminoacylase; N-acylamino-acid amidohydrolase, EC 3.5.1.14, from porcine kidney and the fungus Aspergillus) is broadly applicable enzymatic catalyst for the kinetic resolution of unnatural and rarely occuring α-amino acids.Its enantioselectivity for the hydrolysis of N-acyl L-α-amino acids is nearly absolute, yet it accepts substrates having a wide range of structure and functionality.This paper reports the initial rates of enzyme-catalyzed hydrolysis of over 50 N-acyl amino acids and analogues, the stabilities of the enzymes in aqueous and aqueous/organic solutions, and the effects of different acyl groups and metal ions on the rates of enzymatic hydrolysis.Eleven α-amino and α-methyl α-amino acids were resolved on a 2-29-g scale.Crude L- and D-amino acid products had generally >90percent ee.The utility of resolved amino acids as chiral synthons was illustrated by the preparation of (R)- and (S)-1-butene oxide and the diastereoselective (cis:trans, 7-8:1) iodolactonization of three 2-amino-4-alkenoic acid derivatives.