62778-16-9

Usage

Uses

Used in Polymer and Plastic Industry:
(2-METHYLBENZYL)PHOSPHONIC ACID DIETHYL ESTER is used as a flame retardant additive for its effectiveness in reducing the flammability of polymers and plastics, thereby improving their fire safety.
Used in Paints and Coatings Industry:
(2-METHYLBENZYL)PHOSPHONIC ACID DIETHYL ESTER is used as a flame retardant in paints and coatings to enhance their fire resistance and prevent the spread of fire.
Used in Adhesives Industry:
(2-METHYLBENZYL)PHOSPHONIC ACID DIETHYL ESTER is used as a flame retardant in adhesives to improve their fire safety and reduce the risk of fire in bonded materials.
Used as a Stabilizer and Chelating Agent:
(2-METHYLBENZYL)PHOSPHONIC ACID DIETHYL ESTER is used as a stabilizer and chelating agent in various industrial processes to enhance the performance and safety of the products.

InChI:InChI=1/C12H19O3P/c1-4-14-16(13,15-5-2)10-12-9-7-6-8-11(12)3/h6-9H,4-5,10H2,1-3H3

Upstream product

• 552-45-4 1-chloromethyl-2-methylbenzene 
• 122-52-1 triethyl phosphite 
• 35629-84-6 N'-(2-methylbenzylidene)-4-methylbenzenesulfonohydrazide 
• 762-04-9 phosphonic acid diethyl ester 
• 529-20-4 2-methylphenyl aldehyde 
• 78-40-0 triethyl phosphate 
• 89-92-9 2-methylbenzyl bromide 

Downstream Products

• 147792-90-3 3,4-Bis-(o-methylstyryl)thiophene 
• 36888-18-3 (E)-2,2'-dimethylstilbene 
• 18869-29-9 (E)-4,4'-dimethylstilbene 
• 2510-76-1 (Z)-4,4'-dimethylstilbene 
• 241155-86-2 C₁₈H₂₀O₂ 
• 241155-87-3 1-Bromo-3-tert-butyl-5-((E)-2-o-tolyl-vinyl)-benzene 
• 241155-88-4 (E)-3-[2-(2-methoxyphenyl)ethenyl]benzaldehyde 
• 241155-89-5 3-tert-butyl-5-(2-o-tolyl-vinyl)-benzaldehyde 
• 137349-02-1 diethyl 2-carboxybenzylphosphonate 
• 1197732-53-8 1,2-dicarboxymethyl-3,6-di-o-tolyl-1,2,4,5-cyclohexadiene 
• 1000672-79-6 (E)-2-(2-methylstyryl)-3,5,6-trimethylpyrazine 
• 53423-25-9 (E)-1-methyl-2-styryl-benzene 
• 248589-09-5 (E,E)-3-[2-(2-methylphenyl)ethenyl]-N-phenylbenzaldimine 
• 72398-89-1 2-((Z)-2-o-Tolyl-vinyl)-phenol 

Relevant academic research and scientific papers

Preparation method of 1,4-bis(2-methylstyryl)benzene

The invention relates to a preparation method of 1,4-bis(2-methylstyryl)benzene. The 1,4-bis(2-methylstyryl)benzene is prepared from diethyl methylbenzylphosphonate and terephthalaldehyde through a reaction. Compared with the prior art, the preparation me

Template-Assisted meta-C?H Alkylation and Alkenylation of Arenes

To expand the scope of meta-functionalization, a pyrimidine-based template effective for the formation of β-aryl aldehydes and ketones, using allyl alcohols, by meta-C?H activation of benzylsulfonyl esters is described. In addition, α,β-unsaturated aldehydes were generated by in situ olefination and deprotection of allyl benzyl ethers. These new functionalizations at the meta-position of an arene have also been successfully implemented in benzylphosphonate, phenethyl carbonyl, and phenethylsulfonyl ester scaffolds. Key to these successful new functionalizations is the creation of an electropositive palladium center by accepting the electron cloud from the metal to the energetically low-lying π-orbitals of pyrimidine ring, and it favors coordination of allyl alcohol to the metal center.

Reductive coupling reactions: A new strategy for C(sp3)-P bond formation

The C(sp3)-P bond forming reaction utilizing N-tosylhydrazones as readily available alkylating reagents was developed, which provides a new opportunity for preparing phosphine oxide derivatives with moderate to good yields. This reductive coupling reaction is proposed to proceed through an insertion of copper carbene into P-H bond of H-phosphorus oxides. The salient features of the reaction are operational simplicity and functional-group tolerance.

Copper-catalyzed synthesis of alkylphosphonates from H-phosphonates and N-tosylhydrazones

A new catalytic system for the alkylation of H-phosphonates and diphenylphosphine oxide with N-tosylhydrazones has been developed. In the presence of copper(I) iodide and base, H-phosphonates react with N-tosylhydrazones to afford the corresponding coupled alkylphosphonates in good to excellent yields without any ligands. Alkylphosphonates can also be prepared in a one-pot process directly from carbonyl compounds without the isolation of tosylhydrazone intermediates.

Ligustrazine Derivatives. Part 4: Design, Synthesis, and Biological Evaluation of Novel Ligustrazine-based Stilbene Derivatives as Potential Cardiovascular Agents

A series of novel stilbene derivatives containing ligustrazinyl moiety was designed, synthesized, and assayed for their protective effects on damaged endothelial cells. The results showed that most ligustrazinyl stilbene derivatives exhibited high protective effects on the human umbilical vascular endothelial cells (HUVECs) damaged by hydrogen peroxide in comparison with Ligustrazine. The stilbene derivatives A6, A9, A11, A21, A24, A25, and A27 exhibited high potency with low EC50 values ranged from 0.0249μm to 0.0898mm. Compound A27 displayed EC50 0.0249μm, which is 30000 times higher than that of Ligustrazine, presenting a most promising lead for further investigation. Structure-activity relationships were briefly discussed.

Synthesis and photodimerisation of tetrabenzo[ab,f,jk,o]-[18]annulenes

The tetrabenzo[ab,f,jk,o][18]annulenes 7a,b, generated in a 5-step synthesis, show photodimerisation and -oligomerisation reactions in the solid state and in solution. The state of aggregation determines the reaction route. Whereas the cyclodimer 8a has a simple cyclobutane structure, the dimer 8b is a highly symmetrical cyclophane.

Tetrabenzo[ab,f,jk,o][18]annulene: Synthesis, crystal structure analysis, ab initio quantum-chemical studies of intermolecular interactions in the gas phase and in crystalline states, photodimerization and photopolymerization

The synthesized title compound 8 crystallizes in three different modifications, which were investigated by electron crystallography, high resolution electron microscopy and X-ray structural analysis. The formation of molecular pairs was studied by an ab initio quantum-chemical approach. The calculated "dimers" were compared to the mutual orientations of nearest neighboring molecules in the crystal structures and to covalently bonded dimers obtained by a topochemical photodimerization.

The synthesis of alkenes via epi-phosphonium species: 2. A phosphorus Ramberg-Backlund reaction

Stilbene may be synthesised with Z-selectivity from (α- bromobenzyl)benzyldiphenylphosphonium bromide by the action of amine bases. A series of stilbenes was synthesised by the action of N-bromosuccinimide and 2,2,6,6-tetramethylpiperidine directly upon dibenzyldiphenylphosphonium salts. The reaction, essentially a phosphonium analogue of the Ramberg- Backlund displays cis selectivity. The dibenzyldiphenylphosphonium salts were prepared by the one pot polymethylhydrosiloxane/titanium(IV) isopropoxide mediated reduction/alkylation of benzyldiphenylphosphine oxides.

Use of benzylphosphonic acid derivatives for the treatment of diseases caused by viruses

The use of a compound of the formula I STR1 in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, aryl, aralkyl or carboalkoxy group, R1 and R2 are an alkyl, alkenyl, alkynyl, cycloalkyl or halogenoalkyl group, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium or hydrogen, R1 and R2 together form a cyclic diester, R3 and R4 are an alkyl, alkenyl, alkynyl, carboalkoxy, cycloalkyl or alkoxy group, hydrogen, fluorine, chlorine, bromine or iodine and X, Y and Z are oxygen or sulfur, for the treatment of diseases caused by DNA viruses or RNA viruses is described.

SCHWEFELVERBINDUNGEN DES ERDOELS XV. METHYL-5,6,7,8-TETRAHYDRODINAPHTHOTHIOPHENE UND METHYLDINAPHTHOTHIOPHENE

A one pot synthesis gives methyl-5,6,7,8-tetrahydrodinaphthothiophenes (7) from methyl-1,2,3,4-tetrahydronaphthalen-1-ones (1) by bromination and sulfurization.Tetrahydro compounds 7 have been dehydrogenated to corresponding dinaphthothiophenes 8.Proofs for the constitutions are nmr data of 7, 8 and the independent synthesis of one compound 8.A reaction mechanism with 1,4-dithiine intermediates is discussed. Key words: Alkyl-1,2,3,4-tetrahydronaphthalen-1-ones; alkyl-5,6,7,8-tetrahydrodinaphthothiophenes; alkyldinaphthothiophenes; dehydrogenation with o-chlorobenzoquinone.