627882-29-5

Upstream product

• 495417-33-9 3-(2-chlorophenyl)-5-methylisoxazole-4-carbinol 
• 388608-83-1 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxaldehyde 
• 29568-74-9 2-chloro-N-hydroxybenzimidoyl chloride 
• 4357-94-2 methyl 3-(2'-chlorophenyl)-5-methylisoxazole-4-carboxylate 
• 75-36-5 acetyl chloride 
• 627882-17-1 2-{[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylic acid methyl ester 

Downstream Products

• 884537-21-7 4-acetyl-3-[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]-2-methylene-5-oxohexanoic acid methyl ester 

Relevant academic research and scientific papers

Convenient synthesis of substituted α-methylene-δ- valerolactones in aqueous medium using Baylis-Hillman chemistry

A mild and convenient synthesis of substituted α-methylene-δ- valerolactones was achieved by SN2 nucleophilic substitution of the acetates of Baylis-Hillman adducts with acetyl acetone followed by one-pot saponification of the ester, reduction

Studies on the catalytic hydrogenation of Baylis-Hillman derivatives of substituted isoxazolecarbaldehydes. Unusual retention of isoxazole ring during Pd-C-promoted hydrogenation of Baylis-Hillman adducts

Results of the catalytic hydrogenation of Baylis-Hillman adducts obtained from substituted 3-, 4- and 5-isoxazolecarbox-aldehydes and their corresponding acetates in the presence of Raney-Ni and Pd-C are presented. The hydrogenation of Baylis-Hillman addu

Highly substituted isoxazoles: The Baylis-Hillman reaction of substituted 4-isoxazolecarbaldehydes and attempted cyclization to isoxazole-annulated derivatives

In an attempt to understand the effect of position of the formyl group on the efficiency of Baylis-Hillman reaction within isoxazolecarbaldehydes, the reactions of substituted 4-isoxazolecarbaldehydes to obtain highly substituted isoxazoles are described. Attempts to obtain isoxazole-annulated derivatives from these Baylis-Hillman adducts involving SNR′-SNAr substitution strategy are also described.