62789-50-8

Upstream product

• 95-78-3 2,5-Dimethylaniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 941-55-9 4-toluenesulfonyl azide 
• 106-42-3 para-xylene 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 

Downstream Products

• 3717-94-0 N-(2,5-dimethyl-4-nitrophenyl)-4-methylbenzenesulfonamide 
• 65489-12-5 N-(4-methoxyphenyl)-2,5-dimethylaniline 
• 107816-51-3 N-(3'-methoxyphenyl)-2,5-dimethyl-N-(toluene-p-sulfonyl)aniline 
• 134591-94-9 N-(3',5'-dimethoxyphenyl)-2,5-dimethyl-N-toluene-p-sulfonylaniline 
• 160757-60-8 N-(p-tolylsulfonyl)-4-bromo-2,5-dimethylaniline 
• 160757-63-1 N-(p-tolylsulfonyl)-4-cyano-2,5-dimethylaniline 
• 160757-61-9 N-(p-tolylsulfonyl)-N-(3',5'-dimethoxyphenyl)-4-cyano-2,5-dimethylaniline 
• 176385-58-3 N-(p-tolylsulfonyl)-N-phenyl-4-cyano-2,5-dimethylaniline 
• 176385-57-2 N-(p-tolylsulfonyl)-N-(4'-methoxyphenyl)-4-2,5-dimethylaniline 
• 176385-67-4 3-[N-(2,2-diethoxyethyl)-N-p-tosylaminomethyl]-5,7-dimethoxy-1,4-dimethylcarbazole 

Relevant academic research and scientific papers

Utilization of transition metal fluoride-based solid support catalysts for the synthesis of sulfonamides: Carbonic anhydrase inhibitory activity and: In silico study

The applications of solid support catalysts in catalyzing organic reactions are well-evident. In the present study, we explored a transition metal fluoride (FeF3) adsorbed on molecular sieves (4 ?) as a solid support catalyst for the preparation of sulfon

Organocatalytic Para-Selective Amination of Phenols with Iminoquinone Monoacetals

A highly selective para C-H amination of unprotected phenols with iminoquinone acetals was realized, giving the functional phenols in good to excellent yields. Overall, this transformation is operationally simple, proceeds with readily available phenols, and has wide substrate scope and low catalyst loading. The biarylamine product is stochastically formed via [5,5]-sigmatropic rearrangement of a mixed acetal species which is generated in situ under the reaction conditions.

Transition-metal-free direct amination of simple arenes with sulfonyl azides

A metal-free green protocol has been developed for amination of simple arenes using arylsulfonyl azides via a nitrene transfer process under solvent free conditions at 130 °C releasing N2 gas as the sole by-product.

Half-sandwich scorpionates as nitrene transfer catalysts

Scorpionate complexes of the middle to late 3d transition metals [(L)M(NCMe)3](BF4)n (M = Mn, Fe, Co, Ni: 1 M, L = tris(3,5-dimethylpyrazol-1-yl)methane, TpmMe,Me, n = 2; 2M, L = tris(3-phenylpyrazol-1-yl)methane, TpmPh, n = 2; 3M except 3Mn, L = hydrotris(3,5-dimethylpyrazol-1-yl) borate, [TpMe,Me]-, n = 1; 4M, L = hydrotris(3-phenyl-5-methylpyrazol-1-yl)borate, [TpPh,Me] -, n = 1) were examined as catalysts for styrene aziridination and THF amination using phenyl-N-tosyliodinane as a nitrene donor. [(Tpm Me,Me)Fe(NCMe)3](BF4)2 (1 Fe) was identified as the most active catalyst, giving nearly quantitative nitrene transfer yields at 5 mol % loadings. The reactivity of 1Fe with a wider range of organic substrates was also explored, and a striking observation was strong selectivity for aromatic rather than benzylic amination for alkylaromatic substrates.

A mild and simple synthesis of N-aryl substituted toluenesulfamides under solvent-free conditions

In this paper, a series of N-aryl substituted toluenesulfamides were synthesised by grinding under solvent-free conditions at room temperature. The yields were excellent (88%-97%), and the process is simple.

Photolysis of p-Toluenesulfonyl Azide and Its Charge-Transfer Complex with Aniline

Photolysis of p-toluenesulfonyl azide (1) in p-xylene and cyclohexane gives primarily the products derived from insertion of (p-tolylsulfonyl)nitrene into the solvent.For p-xylene, an unstable intermediate product is formed which decomposes in the dark at room temperature to give both the ring-insertion product and the corresponding p-toluenesulfonamide (2).Photolysis of the ground-state charge-transfer complex between p-toluenesulfonyl azide and aniline gives six products, the major product being the sulfonyl hydrazide 7.Furthermore, formation of the insertion product by reaction with the solvent provides evidence for production of (p-tolylsulfonyl)nitrene from the excited charge-transfer complex.

FACILE SYNTHESIS OF N-SUBSTITUTED 1H-AZEPINE DERIVATIVES

The facile synthesis of N-sulphonyl and N-ethoxycarbonyl substituted 1H-azepines in high yields by the pressure-induced sulphonylnitrene insertion reaction or, in anhydrous solvents, the 1,3-dipolar azide addition reaction with aromatic substrates containing electron-withdrawing substituents (e.g. dimethyl terephthalate) are described.The probable sequences of reactions involved in the two cases have been indicated.