62790-87-8

Basic information

• Product Name: Silane, (1,1-dimethylethyl)(4-methoxyphenoxy)dimethyl-
• CAS NO: 62790-87-8
• Molecular Formula: C13H22O2Si
• Molecular Weight: 238.402
• Mol File: 62790-87-8.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Silane, (1,1-dimethylethyl)(4-methoxyphenoxy)dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, (1,1-dimethylethyl)(4-methoxyphenoxy)dimethyl-(62790-87-8)
• EPA Substance Registry System: Silane, (1,1-dimethylethyl)(4-methoxyphenoxy)dimethyl-(62790-87-8)

Safety Data

• Hazardous Substances Data: 62790-87-8(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 150-76-5 4-methoxy-phenol 
• 4316-42-1 1-Butylimidazole 
• 41879-37-2 t-butyldimethylsilyl amine 
• 678187-53-6 (tert-butyldimethylsilyl)diphenylphosphine 
• 143422-89-3 (2-methylallyl)tertiobutyl-dimethylsilane 
• 1200-06-2 4-methoxyphenyl acetate 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 53451-89-1 4-methoxyphenoxy-4-trifluoromethylphenyl ether 
• 836-07-7 1-iodo-2-(4-methoxyphenoxy)benzene 
• 78338-68-8 4-(4-methoxyphenoxy)benzonitrile 
• 108534-51-6 4-((tert-butyldimethylsilyl)oxy)-4-methoxycyclohexa-2,5-dienone 
• 114251-21-7 4-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-1-methyl-cyclohexa-2,5-dienol 
• 114251-37-5 1-tert-Butyl-4-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-cyclohexa-2,5-dienol 
• 114251-25-1 1-Butyl-4-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-cyclohexa-2,5-dienol 
• 114251-27-3 4-(tert-Butyl-dimethyl-silanyloxy)-1-(3,3-dimethyl-but-1-ynyl)-4-methoxy-cyclohexa-2,5-dienol 
• 114251-29-5 4-(tert-Butyl-dimethyl-silanyloxy)-1-(1-ethoxy-cyclopropyl)-4-methoxy-cyclohexa-2,5-dienol 
• 114251-23-9 4-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-1-phenyl-cyclohexa-2,5-dienol 
• 114251-30-8 4-(tert-Butyl-dimethyl-silanyloxy)-1-(4,5-dimethoxy-2-vinyl-phenyl)-4-methoxy-cyclohexa-2,5-dienol 
• 3753-58-0 (4-methoxyphenyl) benzenesulfonate 

Relevant articles and documents

Spiroketal Formation by Cascade Oxidative Dearomatization: An Approach to the Phorbaketal Skeleton

Addition of PhI(OAc)2 to phenols that have meta-linked hydroxy ketones results in cascade oxidative dearomatizing spirocyclization to give tricyclic spiroketals. This framework is found in the phorbaketal family of natural products.

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs

Diversity Oriented Clicking (DOC) is a unified click-approach for the modular synthesis of lead-like structures through application of the wide family of click transformations. DOC evolved from the concept of achieving “diversity with ease”, by combining classic C?C π-bond click chemistry with recent developments in connective SuFEx-technologies. We showcase 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs) as a new class of connective hub in concert with a diverse selection of click-cycloaddition processes. Through the selective DOC of SASFs with a range of dipoles and cyclic dienes, we report a diverse click-library of 173 unique functional molecules in minimal synthetic steps. The SuFExable library comprises 10 discrete heterocyclic core structures derived from 1,3- and 1,5-dipoles; while reaction with cyclic dienes yields several three-dimensional bicyclic Diels–Alder adducts. Growing the library to 278 discrete compounds through late-stage modification was made possible through SuFEx click derivatization of the pendant sulfonyl fluoride group in 96 well-plates—demonstrating the versatility of the DOC approach for the rapid synthesis of diverse functional structures. Screening for function against MRSA (USA300) revealed several lead hits with improved activity over methicillin.

Overcoming solid handling issues in continuous flow substitution reactions through ionic liquid formation

Substitutions such as acylations, arylations, and alkylations are some of the most commonly run reactions for building complex molecules. However, the requirement of a stoichiometric base to scavange acid by-products creates significant challenges when operating in continuous flow due to solid handling issues associated with precipitating base·HX salts. We present a general and simple strategy to overcome these solid handling issues through the use of acid scavenging organic bases that generate low- to moderate-melting ionic liquids upon protonation. The application of these bases towards the most commonly run substitutions are demonstrated, enabling reactions to be run in flow without requiring additional equipment, specific solvents, or dilute reaction conditions to prevent clogging.