6280-54-2

Usage

Uses

Used in Pharmaceutical Industry:
(3-chlorophenyl)(2-hydroxy-5-methylphenyl)methanone is used as an intermediate compound for the synthesis of various drugs, taking advantage of its methanone functional group and the potential reactivity of its hydroxy and methyl groups.
Used in Chemical Research:
(3-chlorophenyl)(2-hydroxy-5-methylphenyl)methanone is also used as a subject of study in chemical research to explore its potential biological activity, reactivity, and the influence of its chlorine atom on its chemical properties, which could lead to the development of new pharmaceuticals or other applications.

Upstream product

• 6280-49-5 4-methylphenyl 3-chlorobenzoate 

Downstream Products

• 794513-64-7 3-chloro-benzoic acid 2-(3-chloro-benzoyl)-4-methyl-phenyl ester 
• 1578261-60-5 ethyl (N'-{2-[2-(3-chlorobenzoyl)-4-methylphenoxy]acetyl}hydrazinocarbonyl)acetate 
• 1630042-87-3 2 [2 (3 chlorobenzoyl) 4 methylphenoxy]methyl 1,3,4 oxadiazole 
• 677707-52-7 [2-(5-amino-[1,3,4]oxadiazol-2-ylmethoxy)-5-methyl-phenyl]-(3-chloro-phenyl)-methanone 
• 677707-48-1 2-[2-(3-chlorobenzoyl)-4-methylphenoxy]acetohydrazide 
• 871037-26-2 [2-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethoxy)-5-methyl-phenyl]-(3-chloro-phenyl)-methanone 
• 871037-21-7 (3-chloro-phenyl)-[5-methyl-2-(5-thioxo-4,5-dihydro-[1,3,4]oxadiazol-2-ylmethoxy)-phenyl]-methanone 
• 725744-69-4 [2-(3-chlorobenzoyl)-4-methylphenoxy]ethanoic acid 
• 677707-45-8 ethyl [2-(3-chlorobenzoyl)-4-methylphenoxy]acetate 
• 6279-19-2 2-(3-chloro-benzyl)-4-methyl-phenol 

Relevant academic research and scientific papers

Synthesis and crystallographic analysis of benzophenone derivatives-The potential anti-inflammatory agents

Fries rearrangement of substituted phenyl benzoates 1a-j to substituted hydroxy benzophenones 2a-j was achieved in excellent yield. Further benzoylation of 2a-j to benzoyloxy benzophenones 4a-n, a benzophenone analogue was achieved in good yield. All the newly synthesized compounds were evaluated for their anti-inflammatory activity and were compared with standard drugs. Out of the compounds studied, the compounds 4c, 4e, 4g, 4h and 4k with chloro and methyl substituents at para position showed more potent activity than the standard drugs at all doses tested.

Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes

Benzoylation of (hydroxy phenyl) phenyl methanone 2a-g to benzoyl phenyl benzoates 4a-g, a benzophenone analogue, was achieved in good yield. All the newly synthesized compounds were evaluated for their phospholipase A2 [E.C. 3.1.1.4] and hyaluronidase [E.C. 3.2.1.35] enzyme inhibitory activity in snake venom as source and their structure-activity relationship with respect to different groups is reported for the first time. The in vitro PLA2 enzyme inhibitory activity and in vivo anti-inflammatory activity studies of benzoyl phenyl benzoates are illustrated.

Synthesis and anti-inflammatory activity of benzophenone analogues

A series of substituted benzophenone analogues has been synthesized and evaluated as orally active anti-inflammatory agents with reduced side effects. The anti-inflammatory and ulcerogenic activities of the compounds were compared with naproxen, indometha