6280-96-2

Usage

Uses

Used in Medical and Surgical Applications:
2-Propoxyphenol is used as a general anesthetic for inducing and maintaining anesthesia during surgeries or medical procedures. It is administered intravenously and acts as a sedative and hypnotic agent, providing a rapid onset of anesthesia and a quick recovery time.
Used in Anesthesia for Various Surgical Procedures:
2-Propoxyphenol is used as an anesthetic agent in a wide range of surgical procedures, including minor and major surgeries, diagnostic procedures, and endoscopic examinations. Its rapid onset and short duration of action make it suitable for both short and long procedures.
Used as a Sedative and Hypnotic Agent:
2-Propoxyphenol is used as a sedative and hypnotic agent in medical settings, helping to induce a state of calmness and sleepiness in patients. Its sedative effects are achieved by enhancing the effect of gamma-aminobutyric acid (GABA) in the brain.
Used for Antiemetic Properties:
2-Propoxyphenol is used for its antiemetic properties, which help prevent nausea and vomiting after surgery. This is particularly beneficial in patients who are prone to postoperative nausea and vomiting.
Used in Medical Settings with Caution:
While 2-Propoxyphenol is widely used in medical settings, it is important to exercise caution due to its potential for abuse and adverse effects. These can include respiratory depression, low blood pressure, and potential allergic reactions. Proper administration and monitoring by trained medical professionals are essential to ensure patient safety.

InChI:InChI=1/C9H12O2/c1-2-7-11-9-6-4-3-5-8(9)10/h3-6,10H,2,7H2,1H3

Upstream product

• 10467-10-4 ethylmagnesium iodide 
• 60-29-7 diethyl ether 
• 95-47-6 o-xylene 
• 29515-39-7 1-methoxy-2-n-propoxybenzene 
• 540-54-5 1-Chloropropane 
• 120-80-9 benzene-1,2-diol 
• 106-94-5 propyl bromide 
• 274-09-9 Methylenedioxybenzene 
• 7664-41-7 ammonia 
• 1126-20-1 2-allyloxyphenol 
• 7091-12-5 2-n-propoxybenzaldehyde 
• 90-02-8 salicylaldehyde 
• 90-05-1 2-methoxy-phenol 
• 107-08-4 1-iodo-propane 

Downstream Products

• 110943-74-3 4-hydroxy-3-propoxybenzaldehyde 
• 222031-84-7 2-hydroxy-3-n-propoxybenzaldehyde 
• 1005005-55-9 2-allyl-6-propoxy phenol 
• 1005005-88-8 (1-allyloxy-2-propoxybenzene) 
• 1430847-78-1 1-[2-(4-chlorophenyl)-4-(2-propoxyphenoxymethyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole 

Relevant academic research and scientific papers

Direct oxidation of the C(sp2)-C(sp3) bond from benzyltrimethylsilanes to phenols

A novel pathway for direct conversion of benzylsilanes to phenols by oxidation with Na2S2O8 and oxygen is efficiently developed under mild and neutral conditions. The reaction shows good functional group tolerance to afford phenols in moderate yields. The possible mechanism is proposed based on the isotopic labeling trials.

METHODS AND COMPOSITIONS FOR CONTROL OF CABBAGE LOOPER, Trichoplusia ni

The invention provides in part dialkoxybenzene compounds for controlling infestation by a Trichoplusia ni, and methods thereof. The compounds include a compound of Formula I: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl(3-methylbutyl) or allyl; R2 may be at positions 2, 3 or 4 and may be H, methyl, ethyl, propyl, n-butyl, isopentyl(3-methylbutyl) or allyl; and R3 may be optionally present at positions 2, 3 and 4, and is allyl; except that when R2 is at position 2, R3 if present is at position 3, and when R2 is at position 3, R3 if present is at positions 2 or 4, and when R2 is at position 4, R3 if present is at position 2, and when R2 is at position 4 and R3, if present, has reacted with an OH group at position 1 in a Markovnikov sense, then R3 becomes R4, a dihydrofuran.

METHODS AND COMPOSITIONS FOR CONTROL OF GYPSY MOTHS, Lymanria dispar

The invention provides in part dialkoxybenzene and eugenol compounds for controlling infestation by a Lymantria dispar, and methods thereof. The compounds include a compound of Formula I: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; R2 may be at positions 2, 3 or 4 and may be H, methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; and R3 may be optionally present at positions 2, 3 and 4, and is allyl; with the provisos that when R2 is at position 2, R3 if present is at position 3, or when R2 is at to position 3, R3 if present is at positions 2 or 4, or when R2 is at position 4, R3 if present is at position 2; or of Formula II: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; or mixtures thereof.

Dialkoxybenzene and dialkoxyallylbenzene feeding and oviposition deterrents against the cabbage looper, trichoplusia ni: Potential insect behavior control agents

The antifeedant, oviposition deterrent, and toxic effects of individual dialkoxybenzene compounds/sets and of hydroxy- or alkoxy-substituted allylbenzenes, obtained through Claisen rearrangement of substituted allyloxybenzenes, were assessed against the cabbage looper, Trichoplusia ni, in laboratory bioassays. Most of the compounds/sets strongly deterred larval feeding, with some exhibiting mild toxic and oviposition deterrent effects as well. Some of the compounds/sets were more active than the commercial insect repellent, DEET (N,N-diethyl-m-toluamide), as both feeding and oviposition deterrents against the cabbage looper. On the basis of the obtained oviposition data a general hypothesis was proposed regarding the oviposition sites: one binding mode with the alkyl and allyl groups on the same side of the benzene ring resulted in deterrence, the other with alkyl and allyl groups on opposite sides of the benzene ring resulted in stimulation. The results suggest some structure-activity relationships useful in improving the efficacy of the compounds and designing new, nontoxic insect control agents for agriculture.

Asymmetric synthesis of O-protected acyloins using enoate reductases: Stereochemical control through protecting group modification

O-Protected cyclic acyloins were obtained in nonracemic form through asymmetric bioreduction of α,β-unsaturated alkoxy ketones by using 11 different enoate reductases from the "Old Yellow Enzyme" family. The stereochemical outcome of the biotransformation could be switched by variation of the O-protecting group or by the ring size of the substrate, which allows access to both stereoisomers in up to >97 % ee Whereas α-alkoxy enones were readily accepted as substrates, β-analogs were not converted. Overall, α-alkoxy enones represent a novel type of substrate for flavin-dependent ene-reductases. Copyright

Screening of dialkoxybenzenes and disubstituted cyclopentene derivatives against the cabbage looper, Trichoplusia ni, for the discovery of new feeding and oviposition deterrents

The antifeedant, oviposition deterrent, and toxic effects of dialkoxybenzene minilibraries and of disubstituted cyclopentene minilibraries (i.e., consisting of four to five compounds) along with their pure constituent compounds were assessed against third instar larvae and adults of the cabbage looper, Trichoplusia ni, in laboratory bioassays in a search for new insect control agents. These compounds mimic naturally occurring bioactive odorants and tastants and are relatively easily prepared from commodity chemicals. Most of these libraries strongly deterred larval feeding, with some exhibiting strong toxic and oviposition deterrent effects as well. Our results suggest some structure-function relationships within these libraries. Replacement of a methyl group with larger alkyl substituents increased the feeding deterrent effects in most cases. The presence of a free hydroxyl group, irrespective of the carbon framework or alkyl substituent, served to reduce feeding deterrent effects in all series of compounds. Further, exceeding a certain group size also generally had a detrimental effect. This information will be useful in designing new insect control agents for agriculture. Some of these libraries and compounds may have potential for development as commercial insecticides.

Spontaneous resolution among chiral glycerol derivatives: crystallization features of ortho-alkoxysubstituted phenyl glycerol ethers

Five chiral arylglycerol ethers 2-R-C6H4-O-CH2CH(OH)CH2OH (R = OMe, OEt, OPrn, OPri, OBut) have been prepared in racemic and enantiopure form. The melting points and enthalpies of fusion of every species were measured by differential scanning calorimetry. Binary phase diagrams were reconstructed for the whole family, the entropies of the mixing of the enantiomers in the liquid state, and Gibbs free energy of formation of the racemic compound, as well as Pettersson i-values were derived from the thermal data. The differences in the phase behavior of the investigated compounds were associated with the conformations of the alkoxy fragments.

Palladium charcoal-catalyzed deprotection of O-allylphenols

Allyl aryl ethers can be easily cleaved by the use of 10% Pd/C under mild and basic conditions. The present reaction would involve a SET process rather than a π-allyl-palladium complex. The scope and limitation of this new deprotective methodology is also described.

The Baeyer-Villiger Oxidation of Aromatic Aldehydes and Ketones with Hydrogen Peroxide Catalyzed by Selenium Compounds

A series of organoselenium compounds was investigated as activators of hydrogen peroxide in the Baeyer-Villiger oxidation.As a result, a convenient and cheap method for transformation of aromatic aldehydes, having polycondensed ring systems or electron-donating substituents, and polymethoxy derivatives of acetophenone, into phenols was elaborated.This method utilizes hydrogen peroxide activated by areneseleninic acids, as oxidizing agent.