62829-70-3Relevant academic research and scientific papers
Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine
Darvesh, Sultan,McDonald, Robert S.,Darvesh, Katherine V.,Mataija, Diane,Conrad, Sarah,Gomez, Geraldine,Walsh, Ryan,Martin, Earl
, p. 6367 - 6378 (2008/03/27)
Evidence suggests that specific inhibition of butyrylcholinesterase may be an appropriate focus for the development of more effective drugs to treat dementias such as Alzheimer's disease. Butyrylcholinesterase is a co-regulator of cholinergic neurotransmi
Synthesis and psychotropic evaluation of some new N-substitutedbenzothia/ oxazepinylphenothiazines
Bajaj, Kiran,Srivastava,Kumar, Ashok
, p. 157 - 161 (2007/10/03)
A number of N-[2-substitutedaryl-3-substitutedarylaminomethylene-2, 3-dihydro-1,5-benzothia/oxazepin-4-yl]phenothiazines 4a-p and 4a′-p′ have been synthesized from N-[2-substitutedaryl-2, 3-dihydro-1, 5-benzothia/oxazepin-4-yl]phenothiazines by Mannich reaction, on the 3 rd position of benzothia/oxazepine ring. The structure of these compounds have been confirmed by IR, 1H NMR and Mass analysis. The newly synthesized compounds have been evaluated for their psychotropic activities and acute toxicity studies. Compound 4i is found to be most potent compound of this series.
