628292-17-1

Upstream product

• 3536-96-7 vinylmagnesium chloride 
• 628292-12-6 (2S)-1-triphenylmethyl-2-pyrrolidinemethanal 
• 1826-67-1 vinyl magnesium bromide 
• 179918-60-6 (2S)-1-triphenylmethyl-2-pyrrolidinemethanol 
• 147-85-3 L-proline 
• 13515-74-7 (2S)-1-triphenylmethyl-2-pyrrolidinecarboxylic acid 
• 76-83-5 trityl chloride 

Relevant academic research and scientific papers

COMPOUNDS, COMPOSITIONS AND METHODS FOR SYNTHESIS

The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

Enantioselective ring expansion of prolinol derivatives. Two formal syntheses of (-)-swainsonine

Two enantioselective formal syntheses of (-)-swainsonine have been achieved from l-proline by using an enantioselective ring enlargement of substituted prolinols as the key step. The more efficient synthesis has been achieved in 14 steps with an overall yield of 14%.

N-Tritylprolinal: An Efficient Building Block for the Stereoselective Synthesis of Proline-Derived Amino Alcohols

N-Tritylprolinal (prepared in four steps from L-proline) shows a very high Felkin diastereoselectivity in its reaction with various nucleophiles, leading to a straightforward and highly stereoselective access to syn-proline-derived amino alcohols.