628298-45-3Relevant academic research and scientific papers
Synthesis of nα-(1-phenyl-2-mercaptoethyl) amino acids, new building blocks for ligation and cyclization at non-cysteine sites: Scope and limitations in peptide synthesis
Tchertchian, Sylvie,Hartley, Oliver,Botti, Paolo
, p. 9208 - 9214 (2007/10/03)
A new and convenient method for the synthesis and incorporation of N α-(1-phenyl-2-mercaptoethyl)-derivatized amino acids applicable to chemical ligation at non-cysteine sites is presented. Nα- Auxiliary derivatives of glycine and al
Derivatized Amino Acids Relevant to Native Peptide Synthesis by Chemical Ligation and Acyl Transfer
Clive, Derrick L. J.,Hisaindee, Soleiman,Coltart, Don M.
, p. 9247 - 9254 (2007/10/03)
Three amino acids were converted into the derivatives 5.2 (from glycine), 6.4a and 6.4b (from alanine), and 8.3a and 8.3b (from O-benzyl serine). These N-alkylated amino acids, which can be deprotected after conversion of the carboxyl into an amide, correspond to the general structure 2.1, a compound class of use in the study of peptide segment coupling by the ligation-acyl transfer method.
