628325-65-5

Basic information

• Product Name: 4-(3-formyl-3',5'-dimethylbiphenyl-4-yl)piperazine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(3-formyl-3',5'-dimethylbiphenyl-4-yl)piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 628325-65-5
• Molecular Weight: 394.514
• Mol File: 628325-65-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(3-formyl-3',5'-dimethylbiphenyl-4-yl)piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-formyl-3',5'-dimethylbiphenyl-4-yl)piperazine-1-carboxylic acid tert-butyl ester(628325-65-5)
• EPA Substance Registry System: 4-(3-formyl-3',5'-dimethylbiphenyl-4-yl)piperazine-1-carboxylic acid tert-butyl ester(628325-65-5)

Safety Data

• Hazardous Substances Data: 628325-65-5(Hazardous Substances Data)

Upstream product

• 628326-05-6 4-(4-bromo-2-formylphenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 172975-69-8 3,5-dimethylphenyl boronic acid 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 850790-30-6 4-(3-{3-[3-(2-dimethylamino-ethylamino)-phenyl]-3-oxo-propenyl}-3',5'-dimethyl-biphenyl-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Cationic chalcone antibiotics. Design, synthesis, and mechanism of action

This paper describes how the introduction of "cationic" aliphatic amino groups in the chalcone scaffold results in potent antibacterial compounds. It is shown that the most favorable position for the aliphatic amino group is the 2-position of the B-ring, in particular in combination with a lipophilic substituent in the 5-position of the B-ring. We demonstrate that the compounds act by unselective disruption of cell membranes. Introduction of an additional aliphatic amino group in the á-ring results in compounds that are selective for bacterial membranes combined with a high antibacterial activity against both Gram-positive and -negative pathogens. The most potent compound in this study (78) has an MIC value of 2 μM against methicillin resistant Staphylococus aureus.