628330-21-2

Upstream product

• 139386-27-9 ethyl 3-(2-hydroxy-4-methoxyphenyl)-(E)-2-propenoate 
• 100-39-0 benzyl bromide 
• 531-59-9 7-methoxycoumarin 

Downstream Products

• 20921-14-6 ethyl 3-(2'-hydroxy-4'-methoxyphenyl)propanoate 
• 1417997-72-8 (E)-N-hydroxy-2-benzyloxy-4-methoxycinnamamide 
• 1417997-67-1 C₁₇H₁₆O₄ 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors

Histone deacetylases (HDACs) are a family of enzymes that play a crucial role in biological process and diseases. In contrast to other isozymes, HDAC8 is uniquely incapable of histone acetylation. In order to delineate its physiological function, we devel

1,2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY

A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, - O -, - S - and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents -OR4 (R4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.