628330-74-5

Upstream product

• 148872-79-1 3-fluoro-2-[(phenylmethyl)oxy]benzoic acid 

Downstream Products

• 628330-75-6 2-benzyloxy-3-fluorophenylacetonitrile 
• 1292306-52-5 tert-butyl 4-cyano-4-(3-fluoro-2-hydroxyphenyl)piperidine-1-carboxylate 
• 1292306-53-6 C₁₄H₁₂ClFO 
• 1292306-54-7 tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate 
• 628330-77-8 methyl 2-(3-fluoro-2-hydroxyphenyl)acetate 

Relevant academic research and scientific papers

SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF

The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.

1,2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY

A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, - O -, - S - and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents -OR4 (R4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.