148872-79-1

Upstream product

• 394-50-3 3-fluorosalicylaldehyde 
• 100-39-0 benzyl bromide 
• 341-27-5 3-fluorosalicylic acid 
• 584-08-7 potassium carbonate 
• 100-44-7 benzyl chloride 

Downstream Products

• 628330-74-5 2-benzyloxy-3-fluorobenzyl alcohol 
• 938180-01-9 2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-2-thienyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone 
• 705949-54-8 3-fluoro-2-hydroxybenzamide 
• 938180-21-3 2-{3-fluoro-2-[(phenylmethyl)oxy]phenyl}-6-methyl-3-(2-phenylethyl)-4(3H)-pyrimidinone 
• 938177-13-0 5-bromo-2-{3-fluoro-2-[(phenylmethyl)oxy]phenyl}-6-methyl-3-(2-phenylethyl)-4(3H)-pyrimidinone 
• 628330-77-8 methyl 2-(3-fluoro-2-hydroxyphenyl)acetate 
• 1569309-80-3 (2E,6E)-2-(2-(benzyloxy)-3-fluorobenzylidene)-6-(2,3-bis(benzyloxy)benzylidene)cyclohexanone 
• 1429939-31-0 C₅₂H₅₄O₂P₂ 
• 1429939-32-1 (5aR,8aR)-1,13-dis(di-p-tolylphosphanyl)-5a,6,7,8,8a,9-hexahydro-5H-chromeno[3,2-d]xanthene 
• 1292306-54-7 tert-butyl 4-(2-(benzyloxy)-3-fluorophenyl)-4-cyanopiperidine-1-carboxylate 
• 1292306-53-6 C₁₄H₁₂ClFO 
• 1292306-52-5 tert-butyl 4-cyano-4-(3-fluoro-2-hydroxyphenyl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction

The pregnane X receptor (PXR) regulates expression of proteins responsible for all three phases required for the detoxification mechanism, which include CYP450 enzymes, phase II enzymes, and multidrug efflux pumps. Therefore, PXR is a prominent receptor t

Practical asymmetric catalytic synthesis of spiroketals and chiral diphosphine ligands

A practical procedure has been developed for efficient synthesis of chiral aromatic spiroketals and the relevant diphosphine ligands. The procedure includes first asymmetric hydrogenation of readily available α, α'-bis(2-benzyloxyarylidene) ketones cat-al

SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF

The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.

Antibacterial macrocycles with substituted biphenyl

The invention relates to antibacterial macrocycles with substituted biphenyl and processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially of bacterial infections.

1,2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY

A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, - O -, - S - and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents -OR4 (R4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.

1-cyclopropyl-4-pyridyl-quinolinones

Compounds of formula STR1 wherein R1 is hydrogen, lower-alkyl, or trifluoromethyl; R2 is lower-alkyl, trifluoromethyl or CH2 Z where Z is hydroxy, chloro, lower-alkylamino or dilower-alkylamino; R3 and R4 are each individually hydrogen or fluoro; and Ar is phenyl, an aromatic 5- or 6-membered heterocycle or any of these substituted at one or more positions with lower-alkyl, fluoro, chloro, hydroxy, amino, lower-alkylamino, dilower-alkylamino, carboxy, sulfonamido, lower alkylsulfonamido, methylenedioxy, trifluoroacetamido, lower-alkanoylamino, or carbamoyl; and their pharmaceutically acceptable acid addition salts are useful as anticancer agents.